ArticleLight, science & applications2017
Red light at intensities above 10 lx alters sleep-wake behavior in mice.
Article in Light, science & applications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 99 citations in OpenAlex.
- Evaluating chronotypically tailored light therapy for breast cancer survivors: Preliminary findings on fatigue and disrupted sleep.Chronobiology international · 2022Trial
- Melanopic equivalent daylight illuminance of 2 lx maintains and restores physiological and neurophysiological circadian rhythms in rats.Scientific reports · 2026Article
- Wavelength-dependent sleep state manipulation using light pulses in Pogona vitticeps.Communications biology · 2026Article
- The Light-Eye-Brain Axis: Neurobiological Links Between Mood Disorders and Myopia-A Narrative Review.Ophthalmology and therapy · 2026Review
- Seizure-related death exhibits a circadian rhythm independent of seizure timing or sleep in a mouse model of Dravet syndrome.The Journal of physiology · 2025Article
- Influence of lighting on sleep behaviour, circadian rhythm and spontaneous blink rate in stabled riding school horses (Equus caballus).PloS one · 2025Article
- Far-red LED light alters circadian rhythms and elicits dark-adapted ERG responses in rodents.PloS one · 2025Article
- Light-eye-body axis: exploring the network from retinal illumination to systemic regulation.Theranostics · 2025Review
- Effects of Illumination Color on Hypothalamic Appetite-Regulating Gene Expression and Glycolipid Metabolism.Nutrients · 2024Article
- Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Projecting to the Bed Nucleus of the Stria Terminalis Promote Wakefulness and Positive Affective State.Neuroscience bulletin · 2024Article
- Insomnia-related rodent models in drug discovery.Acta pharmacologica Sinica · 2024Review
- GBA-AAV mitigates sleep disruptions and motor deficits in mice with REM sleep behavior disorder.NPJ Parkinson's disease · 2024Article
- One Health: Circadian Medicine Benefits Both Non-human Animals and Humans Alike.Journal of biological rhythms · 2024Review
- A Common Neuronal Ensemble in the Lateral Habenula Regulates Ciprofol Anesthesia in Mice.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Functional aspects of the brain lymphatic drainage system in aging and neurodegenerative diseases.Journal of biomedical research · 2024Article
- Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice.Neuromolecular medicine · 2023Article
- Whole-brain monosynaptic inputs to lateral periaqueductal gray glutamatergic neurons in mice.CNS neuroscience & therapeutics · 2023Article
- Immediate responses to ambient lightiScience · 2023Article
- Acute or Chronic Exposure to Corticosterone Promotes Wakefulness in Mice.Brain sciences · 2023Article
- Dual Modulator of ASIC Channels and GABAInternational journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep is regulated by two mechanisms: the homeostatic process and the circadian clock. Light affects sleep and alertness by entraining the circadian clock, and acutely inducing sleep/alertness, in a manner mediated by intrinsically photosensitive retinal ganglion cells. Because intrinsically photosensitive retinal ganglion cells are believed to be minimally sensitive to red light, which is widely used for illumination to reduce the photic disturbance to nocturnal animals during the dark phase. However, the appropriate intensity of the red light is unknown. In the present study, we recorded electroencephalograms and electromyograms of freely moving mice to investigate the effects of red light emitted by light-emitting diodes at different intensities and for different durations on the sleep-wake behavior of mice. White light was used as a control. Unexpectedly, red light exerted potent sleep-inducing effects and changed the sleep architecture in terms of the duration and number of sleep episodes, the stage transition, and the EEG power density when the intensity was >20 lx. Subsequently, we lowered the light intensity and demonstrated that red light at or below 10 lx did not affect sleep-wake behavior. White light markedly induced sleep and disrupted sleep architecture even at an intensity as low as 10 lx. Our findings highlight the importance of limiting the intensity of red light (⩽10 lx) to avoid optical influence in nocturnal behavioral experiments, particularly in the field of sleep and circadian research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.