ArticleLight, science & applications2017
Subnanometer-resolved chemical imaging via multivariate analysis of tip-enhanced Raman maps.
Article in Light, science & applications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 49 citations in OpenAlex.
- Hyperspectral TERS Imaging Reveals Strain Heterogeneity in Individual Nanoplastic Particles.Nano letters · 2025Article
- Nanoscale chemical analysis of 2D molecular materials using tip-enhanced Raman spectroscopy.Nanoscale · 2023Review
- Surface potential modulation as a tool for mitigating challenges in SERS-based microneedle sensors.Scientific reports · 2022Article
- Multi-Channel Exploration of O Adatom on TiONanomaterials (Basel, Switzerland) · 2020Article
- Super-Resolution Reconstruction of Cell Pseudo-Color Image Based on Raman Technology.Sensors (Basel, Switzerland) · 2019Article
- Correlated Materials Characterization via Multimodal Chemical and Functional Imaging.ACS nano · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tip-enhanced Raman spectroscopy (TERS) is a powerful surface analysis technique that can provide subnanometer-resolved images of nanostructures with site-specific chemical fingerprints. However, due to the limitation of weak Raman signals and the resultant difficulty in achieving TERS imaging with good signal-to-noise ratios (SNRs), the conventional single-peak analysis is unsuitable for distinguishing complex molecular architectures at the subnanometer scale. Here we demonstrate that the combination of subnanometer-resolved TERS imaging and advanced multivariate analysis can provide an unbiased panoramic view of the chemical identity and spatial distribution of different molecules on surfaces, yielding high-quality chemical images despite limited SNRs in individual pixel-level spectra. This methodology allows us to exploit the full power of TERS imaging and unambiguously distinguish between adjacent molecules with a resolution of ~0.4 nm, as well as to resolve submolecular features and the differences in molecular adsorption configurations. Our results provide a promising methodology that promotes TERS imaging as a routine analytical technique for the analysis of complex nanostructures on surfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.