Evidence map›Paper›PMID 30167062›Full record

ArticleThe Pan African medical journal2018

[Exposure of man to metal trace elements and alteration of sperm parameters: study conducted in the mining areas of Haut-Katanga in the Democratic Republic of Congo].

Richard-A-Mutshimbe Mukendi, Célestin Lubaba Nkulu Banza, Clarence-A-Kaut Mukeng, Jules Thaba Moyambe Ngwe, Albert Ntambwe-A-Nkoy Mwembo, Prosper Muenze Kayamba Kalenga

Open access · goldAbstract read
In one paragraph

Article in The Pan African medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Richard-A-Mutshimbe MukendiDépartement de Gynécologie-obstétrique, Cliniques Universitaires de Lubumbashi, Faculté de Médecine, Université de Lubumbashi, République Démocratique du Congo.
Célestin Lubaba Nkulu BanzaUnité de Toxicologie et Environnement, Ecole de Santé Publique, Faculté de Médecine, Université de Lubumbashi, République Démocratique du Congo.
Clarence-A-Kaut MukengUnité de Biostatistique, Ecole de Santé Publique, Faculté de Médecine, Université de Lubumbashi, République Démocratique du Congo.
Jules Thaba Moyambe NgweDépartement de Gynécologie-obstétrique, Cliniques Universitaires de Lubumbashi, Faculté de Médecine, Université de Lubumbashi, République Démocratique du Congo.
Albert Ntambwe-A-Nkoy MwemboDépartement de Gynécologie-obstétrique, Cliniques Universitaires de Lubumbashi, Faculté de Médecine, Université de Lubumbashi, République Démocratique du Congo.
Prosper Muenze Kayamba KalengaDépartement de Gynécologie-obstétrique, Cliniques Universitaires de Lubumbashi, Faculté de Médecine, Université de Lubumbashi, République Démocratique du Congo.
University of Lubumbashi · CD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionArsenic and cadmium exposures cause significant adverse effects. This study aims to determine the urinary arsenic and cadmium concentrations in men in order to analyze their profile in relation to sperm count test values. METHODES: We conducted an exposed-non-exposed analytical study of men exposed to arsenic and cadmium in a mining area in Upper Katanga, DRC and of non-exposed men living far from any mining area.

resultsStudy results show that 48% of exposed subjects had semen pH below the threshold value of 7.2 versus 16% of non-exposed subjects. The risk of a lowering of pH below the standards was more than 4 times higher (OR=4.85[1.9-12.39]) among exposed men. The difference between the averages of the total number of spermatozoa was statistically significant to the advantage of non-exposed subjects. Abnormal number of spermatozoa was much higher in exposed subjects. It was recorded a more rapid spermatozoa mobility degradation in exposed subjects. In addition, 44% of exposed men had urinary arsenic concentration > 20 µg/L versus 8% of non-exposed subjects, the risk of excessive arsenic accumulation was nine times higher in exposed men than in non-exposed men (OR=9.04 [2.82-28.96]). Sixty percent of exposed men had urinary cadmium concentration ≥0.5µg/ml versus 38% of non-exposed subjects, with an Odd Ratio of 2.45 [1.1-5.47], reflecting a risk of excessive cadmium accumulation in exposed men. On the other hand, it was recorded that, among exposed men, high urinary arsenic and cadmium concentrations resulted in a proportional degradation of sperm count test values.

conclusionThis study shows, on one hand, high urinary arsenic and cadmium concentrations and, on the other hand, more rapid and more severe alterations of sperm count test values in men living in mining area. This suggests a decline in male fertility which deserves to be further documented in future studies.

Indexed as

AdolescentAdultArsenicCadmiumDemocratic Republic of the CongoEnvironmental ExposureHumansHydrogen-Ion ConcentrationMaleMiningSemen AnalysisSpermatozoaSperm MotilityTrace ElementsYoung AdultArsenicCadmiumTrace Elementsfertility declineMetal trace elementsmining areas

Identifiers

PMID30167062
PMCPMC6110556
OpenAlexW2804910390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.