Evidence map›Paper›PMID 30167010›Full record

ReviewJournal of arrhythmia2018

Inflammation and atrial fibrillation: A comprehensive review.

Panagiotis Korantzopoulos, Konstantinos P Letsas, Gary Tse, Nikolaos Fragakis, Christos A Goudis, Tong Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of arrhythmia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 10 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 10 syntheses or guidelines pooled it, 209 citations in OpenAlex.

  1. Pooled it
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  3. Beyond the beats: a systematic review of the underlying inflammatory pathways between atrial fibrillation and cognitive decline.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
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  5. The association of coagulation and atrial fibrillation: a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Pooled it
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  11. Trial
  12. Article
  13. Review
  14. Review
  15. Prediabetes and the risk of atrial fibrillation and heart failure: a propensity-matched analysis in a real-world cohort.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  16. Review
  17. Incident atrial fibrillation and pyoderma gangrenosum: long-term thromboembolic, heart failure, and mortality risk.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  18. Article
  19. Review
  20. Article

81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

Panagiotis KorantzopoulosFirst Department of Cardiology Medical School University of Ioannina Ioannina Greece.ORCID 0000-0002-4228-3593
Konstantinos P LetsasSecond Department of Cardiology Laboratory of Cardiac Electrophysiology "Evangelismos" General Hospital of Athens Athens Greece.
Gary TseDepartment of Medicine and Therapeutics Chinese University of Hong Kong Hong Kong China.ORCID 0000-0001-5510-1253
Nikolaos FragakisThird Department of Cardiology Hippokration Hospital Medical School Aristotle University of Thessaloniki Thessaloniki Greece.
Christos A GoudisCardiology Department Serres General Hospital Serres Greece.
Tong LiuDepartment of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China.
Aristotle University of Thessaloniki · GRChinese University of Hong Kong · HKEvangelismos Hospital · GRGeneral Hospital of Serres · GRSecond Hospital of Tianjin Medical University · CNUniversity of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) has different underlying substrates. Atrial remodeling involves electrophysiological and structural abnormalities that promote the development and perpetuation of AF. Experimental and clinical data indicate that inflammation is implicated in the pathophysiology of atrial remodeling. The mechanistic links between atrial remodeling and inflammation are complex while diverse underlying diseases and conditions may affect these pathways. Inflammatory markers have also been associated with AF development, recurrence, perpetuation, total AF burden as well as with thromboembolic complications. The development of specific anti-inflammatory interventions in this setting seems to be challenging and complicated. Several agents with pleiotropic properties, including anti-inflammatory, have been tested in experimental and clinical settings with variable results. This updated review provides a concise overview of all available data regarding the role of inflammation in AF including the predictive role of inflammatory markers. Also, current knowledge and future directions on anti-inflammatory strategies are critically discussed.

Indexed as

anti‐inflammatory interventionsatrial fibrillationatrial remodelingC‐reactive proteininflammation

Identifiers

PMID30167010
PMCPMC6111477
OpenAlexW2807107286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.