ArticleFrontiers in immunology2018
Transforming Growth Factor Beta Signaling in Dendritic Cells Is Required for Immunotolerance to Sperm in the Epididymis.
Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immunoregulatory mechanisms between epithelial clear cells and mononuclear phagocytes in the epididymis.Andrology · 2024Pooled it
- Abnormal Sperm Morphology in Lodpr/lncRNA-HSVIII Knockout Mice with Advancing Age.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Immunological dynamics of the epididymis: from experimental insights to clinical translation.Reproduction & fertility · 2026Review
- Depletion of CX3CR1Mucosal immunology · 2026Article
- Common Environmental Hazards and Male Infertility: Effects on Epididymal Immune Microenvironment.Toxics · 2026Review
- Article
- Basal and Immune Cells of the Epididymis: An Electron Microscopy View of Their Association.Advances in experimental medicine and biology · 2025Review
- Immune Regulation in the Testis and Epididymis.Advances in experimental medicine and biology · 2025Review
- Whole transcriptome sequencing of testis and epididymis reveals genes associated with sperm development in roosters.BMC genomics · 2024Article
- Article
- Myd88 Signaling Is Involved in the Inflammatory Response in LPS-Induced Mouse Epididymitis and Bone-Marrow-Derived Dendritic Cells.International journal of molecular sciences · 2023Article
- CX3CR1 deficiency leads to impairment of immune surveillance in the epididymis.Cellular and molecular life sciences : CMLS · 2022Article
- The Role of Mononuclear Phagocytes in the Testes and Epididymis.International journal of molecular sciences · 2022Review
- Article
- Differential gene expression and hallmarks of stemness in epithelial cells of the developing rat epididymis.Cell and tissue research · 2022Article
- Editorial: The immunology of the male genital tract.Frontiers in immunology · 2022Article
- Integrating miRNA and mRNA Profiling to Assess the Potential miRNA-mRNA Modules Linked With Testicular Immune Homeostasis in Sheep.Frontiers in veterinary science · 2021Article
- From initial segment to cauda: a regional characterization of mouse epididymal CD11cAmerican journal of physiology. Cell physiology · 2020Article
- Differential expression and localisation of TGF-β isoforms and receptors in the murine epididymis.Scientific reports · 2020Article
- Differential Immune Response to Infection and Acute Inflammation Along the Epididymis.Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The epididymis exhibits a less restrictive physical blood-tissue barrier than the testis and, while numerous immunosuppressive factors have been identified in the latter, no mechanisms for epididymal immunotolerance have been identified to date. Therefore, data are currently insufficient to explain how the immune system tolerates the extremely large load of novel antigens expressed on sperm, which become present in the male body after puberty, i.e., long after central tolerance was established. This study tested the hypothesis that transforming growth factor beta (TGFβ) signaling in dendritic cells (DCs) is required for immunotolerance to sperm located in the epididymis, and that male mice lacking TGFβ signaling in DCs would develop severe epididymal inflammation. To test this, we employed adult
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