ArticleCurrent opinion in colloid & interface science2018
From electron crystallography of 2D crystals to MicroED of 3D crystals.
Article in Current opinion in colloid & interface science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Comprehensive microcrystal electron diffraction sample preparation for cryo-EM.Nature protocols · 2025Review
- AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography.Acta crystallographica. Section D, Structural biology · 2024Article
- Micropatterning Transmission Electron Microscopy Grids to Direct Cell Positioning within Whole-Cell Cryo-Electron Tomography Workflows.Journal of visualized experiments : JoVE · 2021Article
- An Overview of Microcrystal Electron Diffraction (MicroED).Annual review of biochemistry · 2021Review
- Selecting a stable solid form of remdesivir using microcrystal electron diffraction and crystal structure prediction.RSC advances · 2021Article
- Microcrystal Electron Diffraction for Molecular Design of Functional Non-Fullerene Acceptor Structures.Chemistry of materials : a publication of the American Chemical Society · 2021Article
- Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.Structure (London, England : 1993) · 2019Article
- Macromolecular Nanocrystal Structural Analysis with Electron and X-Rays: A Comparative Review.Molecules (Basel, Switzerland) · 2019Review
- Collection of Continuous Rotation MicroED Data from Ion Beam-Milled Crystals of Any Size.Structure (London, England : 1993) · 2019Article
- The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination.ACS central science · 2018Article
- Machining protein microcrystals for structure determination by electron diffraction.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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2 authors.
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Abstract
Electron crystallography is widespread in material science applications, but for biological samples its use has been restricted to a handful of examples where two-dimensional (2D) crystals or helical samples were studied either by electron diffraction and/or imaging. Electron crystallography in cryoEM, was developed in the mid-1970s and used to solve the structure of several membrane proteins and some soluble proteins. In 2013, a new method for cryoEM was unveiled and named Micro-crystal Electron Diffraction, or MicroED, which is essentially three-dimensional (3D) electron crystallography of microscopic crystals. This method uses truly 3D crystals, that are about a billion times smaller than those typically used for X-ray crystallography, for electron diffraction studies. There are several important differences and some similarities between electron crystallography of 2D crystals and MicroED. In this review, we describe the development of these techniques, their similarities and differences, and offer our opinion of future directions in both fields.
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