ArticleTransactions of the American Clinical and Climatological Association2018
CELL FATE DETERMINATION IN 3D: REGULATION OF GENE EXPRESSION VIA CHROMATIN INTERACTIONS WITH THE NUCLEAR MEMBRANE.
Article in Transactions of the American Clinical and Climatological Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In the nucleus of all cells, DNA is packaged in association with histone proteins to form chromatin. It is becoming increasingly clear that the organization of chromatin in three dimensions within the nucleus is highly regulated and can contribute to gene expression and cell function. The regions of the genome that are near the nuclear periphery are termed "lamin associated domains" or LADs (1-3). Here, I present a theory, based on recent results, for "chromatin competence" in which the organization of LADs in a progenitor cell accounts for the ability of that cell to respond to external factors to promote differentiation into one lineage or another. I propose that a cell can only respond to an inductive cue if the downstream genes are available for activation, and that genes are not available for activation if they are sequestered in LADs.
Indexed as
Identifiers
30166706PMC6116621W3017249304What OpenQuestion holds
Registered trials
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