ArticlePediatric research2018
Independent and combined associations of physical fitness components with inflammatory biomarkers in children and adolescents.
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Muscular Fitness and Cardiometabolic Variables in Children and Adolescents: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Physical Education's Role in Enhancing Fitness Among Children and Adolescents: A Bibliometric Analysis.Journal of multidisciplinary healthcare · 2026Review
- Associations Between Handgrip Strength and Markers of Insulin Resistance and Inflammation in Childhood and Adolescence: A Systematic Review With Meta-Analysis.Translational sports medicine · 2026Review
- The endurance effort on a mechanical treadmill does not activate the complement system among trained young women.PloS one · 2026Article
- Physical Fitness, Experiential Avoidance, and Psychological Inflexibility Among Adolescents: Results from the EHDLA Study.Children (Basel, Switzerland) · 2025Article
- Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence.Communications biology · 2024Article
- Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- A genetic correlation and bivariate genome-wide association study of grip strength and depression.PloS one · 2022Article
- Changes in Specific Biomarkers Indicate Cardiac Adaptive and Anti-inflammatory Response of Repeated Recreational SCUBA Diving.Frontiers in cardiovascular medicine · 2022Article
- Muscle strength and its association with cardiometabolic variables in adolescents: does the expression of muscle strength values matter?World journal of pediatrics : WJP · 2021Article
- Association Between Changes in Muscle Strength and Risk of Depressive Symptoms Among Chinese Female College Students: A Prospective Cohort Study.Frontiers in public health · 2021Article
- Meeting the Physical Activity Recommendations and Its Relationship with Obesity-Related Parameters, Physical Fitness, Screen Time, and Mediterranean Diet in Schoolchildren.Children (Basel, Switzerland) · 2020Article
- Effect of Aerobic and Anaerobic Exercise on the Complement System of Proteins in Healthy Young Males.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to examine the independent and combined associations of cardiorespiratory fitness, muscular fitness, and motor ability with single and clustered inflammatory biomarkers in children and adolescents.
methodsThis study included 503 children and adolescents. Cardiorespiratory fitness, upper- and lower-muscular fitness, and motor ability were assessed using field-based tests. Fasting blood samples were obtained to determine the levels of a set of inflammatory biomarkers. Global physical fitness and clustered inflammatory biomarker scores were computed. Associations between physical fitness and inflammatory biomarkers were analyzed through linear regression. Differences in inflammatory biomarker levels between physical fitness tertiles were tested.
resultsGlobal physical fitness was inversely associated with single and clustered inflammatory biomarkers in children (p < 0.05); and with C-reactive protein, complement factor C4, leptin, and clustered inflammatory biomarkers in adolescents (p < 0.025). Cardiorespiratory fitness and upper-muscular fitness were negatively and independently associated with several single and clustered inflammatory biomarkers in children and adolescents (p < 0.05). Differences were found between the lowest and the highest tertiles of global physical fitness in clustered inflammatory biomarker levels (p < 0.010).
conclusionPhysical fitness was negatively associated with single and clustered inflammatory biomarkers, independently of body mass index. Increasing physical fitness levels in youth might contribute to reduce the cardiovascular risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.