Evidence map›Paper›PMID 30166549›Full record

ArticleNature communications2018

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.

A Laustsen, R O Bak, C Krapp, L Kjær, J H Egedahl, C C Petersen, S Pillai, H Q Tang, N Uldbjerg, M Porteus and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

  1. Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Human CD34Frontiers in immunology · 2024
    Article
  9. Article
  10. Plasmacytoid Dendritic Cells as a Novel Cell-Based Cancer Immunotherapy.International journal of molecular sciences · 2022
    Review
  11. Review
  12. Review
  13. Dendritic Cell-Based Immunotherapy in Hot and Cold Tumors.International journal of molecular sciences · 2022
    Review
  14. Ly6DNature communications · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Vaccine delivery systems toward lymph nodes.Advanced drug delivery reviews · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

A LaustsenDepartment of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, 8000, Aarhus C, Denmark.
R O BakDepartment of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, 8000, Aarhus C, Denmark.ORCID http://orcid.org/0000-0002-7383-0297
C KrappDepartment of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, 8000, Aarhus C, Denmark.
L KjærDepartment of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, 8000, Aarhus C, Denmark.
J H EgedahlDepartment of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, 8000, Aarhus C, Denmark.
C C PetersenDepartment of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, 8000, Aarhus C, Denmark.
S PillaiUniversity of California, San Francisco, Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, 94118-4417, CA, USA.
H Q TangDepartment of Obstetrics and Gynaecology, Aarhus University Hospital Skejby, Aarhus, 8200, Denmark.
N UldbjergDepartment of Obstetrics and Gynaecology, Aarhus University Hospital Skejby, Aarhus, 8200, Denmark.
M PorteusDepartment of Pediatrics, Stanford University, Stanford, CA, 94305, USA.
N R RoanDepartment of Urology, University of California, San Francisco, CA, 94158, USA.
M NyegaardDepartment of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, 8000, Aarhus C, Denmark.ORCID http://orcid.org/0000-0002-2967-6624
P W DentonDepartment of Infectious Diseases, Aarhus University Hospital Skejby, Aarhus, 8200, Denmark.ORCID http://orcid.org/0000-0003-2458-8147
M R JakobsenDepartment of Biomedicine, Aarhus University, Wilhelm Meyers Alle 4, 8000, Aarhus C, Denmark. mrj@biomed.au.dk.ORCID http://orcid.org/0000-0001-8847-9201
Aarhus University · DKAarhus University Hospital · DKGladstone Institutes · USStanford University · USUniversity of California, San Francisco · US

Funding

Elucidating the mechanism of progesterone-induced permissivity in the upperfemale reproductive tractR01AI127219 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROAN, NADIA R · 2016 to 2020
$2.1M
Lundbeckfonden (Lundbeck Foundation) R194-2015-1388NIAID NIH HHS R01 AI127219Sundhed og Sygdom, Det Frie Forskningsråd (Medical Sciences, Danish Council for Independent Research) 4004-00237
6 · The paper itself

Abstract

Plasmacytoid dendritic cells (pDC) are essential for immune competence. Here we show that pDC precursor differentiated from human CD34

Indexed as

Antigens, CD34Cell DifferentiationCells, CulturedCRISPR-Cas SystemsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDEAD Box Protein 58Dendritic CellsEnzyme-Linked Immunosorbent AssayGene EditingHumansInterferon Type IInterleukin-6NucleotidyltransferasesPolymerase Chain ReactionReceptor, Interferon alpha-betaReceptors, ImmunologicAntigens, CD34cGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDEAD Box Protein 58Interferon Type IInterleukin-6NucleotidyltransferasesReceptor, Interferon alpha-betaReceptors, ImmunologicRIGI protein, humanTLR7 protein, humanTLR9 protein, humanToll-Like Receptor 7Toll-Like Receptor 9

Identifiers

PMID30166549
PMCPMC6117296
OpenAlexW2888160518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.