ArticleNature communications2018
Ethanol facilitates socially evoked memory recall in mice by recruiting pain-sensitive anterior cingulate cortical neurons.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 66 citations in OpenAlex.
- Individual differences in prosocial learning are represented in the hippocampal dorsal CA1.Nature neuroscience · 2026Article
- Increased c-Fos expression in lateral habenula during social transmission of negative valence in prairie voles.Molecular autism · 2026Article
- The Anterior Cingulate Cortex and Prosocial Behavior toward Others in Negative State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology.Annals of neurology · 2026Review
- Rac1 in parvalbumin neurons of the medial prefrontal cortex governs rapid forgetting of social memory.Molecular psychiatry · 2025Article
- Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation.iScience · 2025Article
- Article
- Cortical representations of affective pain shape empathic fear in male mice.Nature communications · 2025Article
- Research progress on the mechanisms of pain empathy.Ibrain · 2025Review
- Oxytocin-induced birth causes sex-specific behavioral and brain connectivity changes in developing rat offspring.iScience · 2024Article
- Understanding Others' Distress Through Past Experiences: The Role of Memory Engram Cells in Observational Fear.Advances in neurobiology · 2024Review
- Hippocampal ensemble dynamics and memory performance are modulated by respiration during encoding.Nature communications · 2023Article
- How social information impacts action in rodents and humans: the role of the prefrontal cortex and its connections.Neuroscience and biobehavioral reviews · 2023Review
- Article
- Watch and Learn: Vicarious Threat Learning across Human Development.Brain sciences · 2021Review
- Ethanol modulation of cortico-basolateral amygdala circuits: Neurophysiology and behavior.Neuropharmacology · 2021Review
- Alcohol and oxytocin: Scrutinizing the relationship.Neuroscience and biobehavioral reviews · 2021Review
- Article
- Indispensable role of the oxytocin receptor for allogrooming toward socially distressed cage mates in female mice.Journal of neuroendocrinology · 2021Article
- MeCP2 Levels Regulate the 3D Structure of Heterochromatic Foci in Mouse Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alcohol is a traditional social-bonding reinforcer; however, the neural mechanism underlying ethanol-driven social behaviors remains elusive. Here, we report that ethanol facilitates observational fear response. Observer mice exhibited stronger defensive immobility while observing cagemates that received repetitive foot shocks if the observer mice had experienced a brief priming foot shock. This enhancement was associated with an observation-induced recruitment of subsets of anterior cingulate cortex (ACC) neurons in the observer mouse that were responsive to its own pain. The vicariously activated ACC neurons projected their axons preferentially to the basolateral amygdala. Ethanol shifted the ACC neuronal balance toward inhibition, facilitated the preferential ACC neuronal recruitment during observation, and enhanced observational fear response, independent of an oxytocin signaling pathway. Furthermore, ethanol enhanced socially evoked fear response in autism model mice.
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