ArticleScience (New York, N.Y.)2018
Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.
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Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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93citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
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93 citing papers in PubMed, 181 citations in OpenAlex.
- A Practical Compass to Biological Digital Resources and Omics Integration in Ewing Sarcoma.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Combined inhibition of CDK4/6 and PI3K pathways exhibit highly synergistic activity and translational potential in Ewing sarcoma.Translational oncology · 2026Article
- EWSR1::FLI1 promotes neocentromere formation in ewing sarcoma cells.Cell reports · 2026Article
- Immunotherapy for pediatric solid tumors: overcoming biological barriers through rational multimodal combinations.Cancer immunology, immunotherapy : CII · 2026Review
- Potential biomarkers of Ewing sarcoma identified through a Europe-wide analysis of prospectively collected samples.Scientific reports · 2026Article
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- Molecular Characterization Informs Prognosis in Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025Article
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- The Puzzle of Genetic Stability and Chromosomal Copy Number Alterations for the Therapy of Ewing Sarcoma.Cancers · 2025Review
- Structural variants in the 3D genome as drivers of disease.Nature reviews. Genetics · 2025Review
- Human Papillomavirus Integration Induces Oncogenic Host Gene Fusions in Oropharyngeal Cancers.Cancer discovery · 2025Article
- Chromoanagenesis in Osteosarcoma.Biomolecules · 2025Review
- Article
- Targeting metastasis in paediatric bone sarcomas.Molecular cancer · 2025Review
- Chromoplexy: A Pathway to Genomic Complexity and Cancer Development.International journal of molecular sciences · 2025Review
- Exploring the Potential of Optical Genome Mapping in the Diagnosis and Prognosis of Soft Tissue and Bone Tumors.International journal of molecular sciences · 2025Article
- Rare germline structural variants increase risk for pediatric solid tumors.Science (New York, N.Y.) · 2025Article
- Structural and Mechanistic Diversity of Constitutional Chromoanagenesis.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The Evolutionary Potential of Chromoanagenesis.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Chromoplexy.Methods in molecular biology (Clifton, N.J.) · 2025Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
38 authors at 13 institutions in 5 countries.
Nathaniel D AndersonProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-4523-6327
Richard de BorjaProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-8181-6348
Matthew D YoungWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.ORCID 0000-0003-0937-5290
Fabio FuligniProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Andrej RosicProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-7806-6964
Nicola D RobertsWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.ORCID 0000-0002-0469-1043
Simon HajjarProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Mehdi LayeghifardProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-6224-3628
Ana NovokmetProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Paul E KowalskiProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Matthew AnakaProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Scott DavidsonDepartment of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-5194-4958
Mehdi ZarreiThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Badr Id SaidProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-9389-1954
L Christine SchreinerProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-6750-5113
Remi MarchandProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-5465-098X
Joseph SitterProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-0541-6649
Nalan GokgozLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.ORCID 0000-0003-3229-1837
Ledia BrungaProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-0343-937X
Garrett T GrahamDepartment of Oncology and Pediatrics, Georgetown University, Washington, DC, USA.ORCID 0000-0002-1097-0962
Anthony FullamWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.ORCID 0000-0002-0884-8124
Nischalan PillayUniversity College London Cancer Institute, Huntley Street, London, UK.ORCID 0000-0003-0579-4105
Jeffrey A ToretskyDepartment of Oncology and Pediatrics, Georgetown University, Washington, DC, USA.ORCID 0000-0003-3619-2879
Akihiko YoshidaDepartment of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
Tatsuhiro ShibataDivision of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan.
Markus MetzlerDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.ORCID 0000-0002-4523-1676
Gino R SomersDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Stephen W SchererProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-8326-1999
Adrienne M FlanaganHistopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK.
Peter J CampbellWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.
Joshua D SchiffmanDepartments of Pediatrics and Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-6968-7694
Mary ShagoDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-7386-2504
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, La Jolla, San Diego, CA, USA.ORCID 0000-0003-3596-4515
Jay S WunderUniversity Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID 0000-0002-5978-9400
Irene L AndrulisLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.ORCID 0000-0002-4226-6435
David MalkinProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. adam.shlien@sickkids.ca sb31@sanger.ac.uk david.malkin@sickkids.ca.ORCID 0000-0001-5752-9763
Sam BehjatiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. adam.shlien@sickkids.ca sb31@sanger.ac.uk david.malkin@sickkids.ca.ORCID 0000-0002-6600-7665
Adam ShlienProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. adam.shlien@sickkids.ca sb31@sanger.ac.uk david.malkin@sickkids.ca.ORCID 0000-0002-0368-5370
Hospital for Sick Children · CAUniversity of Toronto · CAWellcome Sanger Institute · GBGeorgetown University · USRoyal National Orthopaedic Hospital · GBUniversity of Cambridge · GBLunenfeld-Tanenbaum Research Institute · CAMount Sinai Hospital · CAThe University of Tokyo · JPTokyo National Hospital · JPUniversitätsklinikum Erlangen · DEUniversity of California San Diego · USUniversity of Utah · US
Funding
Cancer Research UK 18387Wellcome Trust 110104
Abstract
Sarcomas are cancers of the bone and soft tissue often defined by gene fusions. Ewing sarcoma involves fusions between
Indexed as
Gene RearrangementAdolescentBone NeoplasmsChildDNA ReplicationEvolution, MolecularFemaleGenome, HumanHumansMaleMutationNeoplasm MetastasisNeoplasm Recurrence, LocalOncogene Proteins, FusionSarcoma, EwingSoft Tissue NeoplasmsEWSR1-FLI1 fusion protein, humanOncogene Proteins, Fusion
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.