ArticleThe EMBO journal2018
CRL4
Open access · bronzeAbstract read
In one paragraph
Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- CUL5-mediated ubiquitination in cancer cell therapy: context-dependent roles, molecular networks, and emerging therapeutic avenues.Frontiers in medicine · 2026Review
- Rab40 GTPases regulate AMBRA1-mediated transcription and cell migration.Journal of cell science · 2025Article
- Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors.Genome biology · 2024Article
- Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases.Autophagy · 2024Review
- Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.Nature communications · 2024Article
- Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis.Journal of experimental & clinical cancer research : CR · 2023Article
- Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction.Biological research · 2023Article
- AMBRA1 p.Gln30Arg Mutation, Identified in a Cowden Syndrome Family, Exhibits Hyperproliferative Potential in hTERT-RPE1 Cells.International journal of molecular sciences · 2022Article
- A functional map of HIV-host interactions in primary human T cells.Nature communications · 2022Article
- AMBRA1 and its role as a target for anticancer therapy.Frontiers in oncology · 2022Review
- The Long-Lost Ligase: CRL4DNA and cell biology · 2021Article
- AMBRA1 Negatively Regulates the Function of ALDH1B1, a Cancer Stem Cell Marker, by Controlling Its Ubiquitination.International journal of molecular sciences · 2021Article
- Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling.Acta neuropathologica · 2021Article
- Article
- ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.Cell host & microbe · 2019Article
- Mitophagy in Cancer: A Tale of Adaptation.Cells · 2019Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 3 institutions in 1 country.
Si-Han ChenDepartment of Cellular and Molecular Pharmacology, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA, USA.
Gwendolyn M JangDepartment of Cellular and Molecular Pharmacology, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA, USA.
Ruth HüttenhainDepartment of Cellular and Molecular Pharmacology, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA, USA.
David E GordonDepartment of Cellular and Molecular Pharmacology, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA, USA.
Dan DuDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3470-2890
Billy W NewtonDepartment of Cellular and Molecular Pharmacology, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA, USA.
Jeffrey R JohnsonDepartment of Cellular and Molecular Pharmacology, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA, USA.
Joseph HiattMedical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.
Judd F HultquistDepartment of Cellular and Molecular Pharmacology, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA, USA.
Tasha L JohnsonDepartment of Cellular and Molecular Pharmacology, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA, USA.
Yi-Liang LiuDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Lily A BurtonDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Jordan YeDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Kurt M ReichermeierCalifornia Institute of Technology, Pasadena, CA, USA.
Robert M StroudQuantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.
Alexander MarsonQuantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.
Jayanta DebnathDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.
John D GrossQuantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1377-4705
Nevan J KroganDepartment of Cellular and Molecular Pharmacology, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, CA, USA nevan.krogan@ucsf.edu.ORCID 0000-0003-4902-337X
QB3 · USUniversity of California, San Francisco · USCalifornia Institute of Technology · US
Funding
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6MX-ray Screening and Rapid Structure DeterminationP50GM082250 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRANKEL, ALAN D · 2007 to 2018
$48.8MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MMicrobial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5MAutophagy in Adhesion and MetastasisR01CA126792 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jayanta Debnath · 2009 to 2026
$5.3MDiscovery of novel, ubiquitin-regulated mechanisms of TB control by macrophagesR01AI120694 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COX, JEFFERY S, KROGAN, NEVAN J · 2015 to 2019
$3.3MStructure and Function of the Decapping Enzyme ComplexR01GM078360 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GROSS, JOHN D · 2009 to 2018
$2.5MThe Influence of Early Integration Events on HIV Latency and Reactivation PotentialK22AI136691 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HULTQUIST, JUDD F · 2018 to 2019
$269kNCI NIH HHS R01 CA126792NIAID NIH HHS K22 AI136691NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI120694NIAID NIH HHS T32 AI060537NIGMS NIH HHS P50 GM082250NIGMS NIH HHS R01 GM078360NIGMS NIH HHS T32 GM007618Wellcome Trust
Abstract
Multi-subunit cullin-RING ligases (CRLs) are the largest family of ubiquitin E3 ligases in humans. CRL activity is tightly regulated to prevent unintended substrate degradation or autocatalytic degradation of CRL subunits. Using a proteomics strategy, we discovered that CRL4
Indexed as
ProteolysisSignal TransductionUbiquitinationAdaptor Proteins, Signal TransducingElonginHEK293 CellsHIV-1HIV InfectionsHumansInterleukin-6Receptors, Interleukin-17Suppressor of Cytokine Signaling 3 ProteinUbiquitin-Protein Ligasesvif Gene Products, Human Immunodeficiency VirusAdaptor Proteins, Signal TransducingAMBRA1 protein, humanELOC protein, humanElonginIL17RB protein, humanIL6 protein, humanInterleukin-6Receptors, Interleukin-17SOCS3 protein, humanSuppressor of Cytokine Signaling 3 ProteinUbiquitin-Protein Ligasesvif Gene Products, Human Immunodeficiency Virusvif protein, Human immunodeficiency virus 1AMBRA1cullin‐RING ligaseHIV infectioninterleukin‐6ubiquitin
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.