ArticleNucleic acids research1986
Structural organization and nucleotide sequence of mouse c-myb oncogene: activation in ABPL tumors is due to viral integration in an intron which results in the deletion of the 5' coding sequences.
Article in Nucleic acids research, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Methodological landscape in the field of integration site identification of retroviruses and retroviral vectors.Frontiers in bioengineering and biotechnology · 2025Review
- Uncoupling the Folding and Binding of an Intrinsically Disordered Protein.Journal of molecular biology · 2018Article
- The use of retroviral vectors for gene therapy-what are the risks? A review of retroviral pathogenesis and its relevance to retroviral vector-mediated gene delivery.Genetic vaccines and therapy · 2004Article
- Review
- Oncogene activation in myeloid leukemias by Graffi murine leukemia virus proviral integration.Journal of virology · 1999Article
- Novel integration sites at the distal 3' end of the c-myb locus in retrovirus-induced promonocytic leukemias.Journal of virology · 1995Article
- Genomic organization and chromosomal localization of the mouse synexin gene.The Biochemical journal · 1994Article
- The Myb and Ahi-1 genes are physically very closely linked on mouse chromosome 10.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Long-range mapping of Mis-2, a common provirus integration site identified in murine leukemia virus-induced thymomas and located 160 kilobase pairs downstream of Myb.Journal of virology · 1993Article
- New sites of proviral integration associated with murine promonocytic leukemias and evidence for alternate modes of c-myb activation.Journal of virology · 1992Article
- Transformation of chicken myelomonocytic cells by a retrovirus expressing the v-myb oncogene from the long terminal repeats of avian myeloblastosis virus but not Rous sarcoma virus.Journal of virology · 1992Article
- Activation of the c-ski oncogene by overexpression.Journal of virology · 1991Article
- Acute myeloid leukemia induction by amphotropic murine retrovirus (4070A): clonal integrations involve c-myb in some but not all leukemias.Journal of virology · 1991Article
- The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- Preferential nuclear compartmentalization of endogenous mink cell focus-forming-related retroviral transcripts.The Journal of experimental medicine · 1990Article
- Transcriptionally active genome regions are preferred targets for retrovirus integration.Journal of virology · 1990Article
- Characterization of the sequence-specific interaction of mouse c-myb protein with DNA.The EMBO journal · 1990Article
- Regions of the Moloney murine leukemia virus genome specifically related to induction of promonocytic tumors.Journal of virology · 1990Article
- Structure and biological activity of the transcriptional initiation sequences of the murine c-myb oncogene.Nucleic acids research · 1989Article
- Differential binding of nuclear factors to the intron 1 sequences containing the transcriptional pause site correlates with c-myb expression.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteriophage libraries of mouse DNA were screened for sequences homologous to the v-myb oncogene and two overlapping clones containing the v-myb related region were isolated. Restriction enzyme mapping, heteroduplex analysis and nucleotide sequence analysis revealed the presence of nine exons. Six of these exons are homologous to the v-myb region while the other three exons are derived from the 5' region which is deleted in the viral oncogene. The sequences downstream to the sixth v-myb exon are not included in the 17 kbp of DNA sequences analyzed in this study. Comparison of the structure of the normal c-myb clone with its rearranged couterpart present in plasmacytoid lymphosarcomas revealed that the rearrangements occur in this locus as a result of viral integration. Present studies demonstrate that such a viral insertion interrupts the c-myb coding region at a region identical to that observed in the generation of the v-myb gene of avian myeloblastosis virus and results in the synthesis of mRNAs that lack the same 5' coding region.
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