Evidence map›Paper›PMID 30166402›Full record

ArticleMolecular cancer therapeutics2018

Augmentation of

Niranjan Awasthi, Margaret A Schwarz, Changhua Zhang, Roderich E Schwarz

2 registry-linked trialsAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02027428 phase3completednot on this map

A Phase III, Randomized, Open-Label, Multi-Center, Safety and Efficacy Study to Evaluate Nab-Paclitaxel (Abraxane®) as Maintenance Treatment After Induction With Nab-Paclitaxel Plus Carboplatin in Subjects With Squamous Cell Non-Small Cell Lung Cancer (NSCLC)

TypeinterventionalSponsorCelgeneRan2014 to 2019Enrolled427ConditionsSquamous Cell Carcinoma, Non-Small-Cell LungArmsAbraxane (Induction), Carboplatin (Induction), Abraxane (Maintenance), Best Supportive Care (Maintenance)
NCT02250326 phase2completednot on this map

A Phase 2, Open-Label, Multi-Center Study to Assess Safety and Efficacy of Second/Third-Line Treatment With NAB®-Paclitaxel (ABI-007) In Combination With Epigenetic Modifying Therapy Of CC-486, Or Immunotherapy of Durvalumab (MEDI4736), Or As Monotherapy In Subjects With Advanced Non-Small Cell Lung Cancer (NSCLC): Abound.2L+

TypeinterventionalSponsorCelgeneRan2015 to 2023Enrolled240ConditionsCarcinoma, Non-Small-Cell LungArmsnab-paclitaxel IV, CC-486, Duravalumab
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Tumor vessel normalization and immunotherapy in gastric cancer.Therapeutic advances in medical oncology · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Niranjan AwasthiDepartment of Surgery, Indiana University School of Medicine, South Bend, Indiana. nawasthi@iupui.edu.
Margaret A SchwarzHarper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana.
Changhua ZhangDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Roderich E SchwarzDepartment of Surgery, Indiana University School of Medicine, South Bend, Indiana.

Funding

EMAP II: Pulmonary Vascular MediatorR01HL114977 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SCHWARZ, MARGARET A · 2012 to 2015
$1.8M
NHLBI NIH HHS R01 HL114977
6 · The paper itself

Abstract

Gastric adenocarcinoma (GAC) remains the third most common cause of cancer-related deaths worldwide. Systemic chemotherapy is commonly recommended as a fundamental treatment for metastatic GAC; however, standard treatment has not been established yet. Angiogenesis plays a crucial role in the progression and metastasis of GAC. We evaluated therapeutic benefits of mechanistically diverse antiangiogenic agents in combination with

Indexed as

Xenograft Model Antitumor AssaysAdenocarcinomaAlbuminsAngiogenesis InhibitorsAnimalsAntibodies, MonoclonalAntineoplastic Combined Chemotherapy ProtocolsApoptosisCell Line, TumorCell ProliferationFemaleHumansIndolesMice, Inbred NODMice, SCIDMicrovessels130-nm albumin-bound paclitaxelAlbuminsAngiogenesis InhibitorsAntibodies, MonoclonalDC101 monoclonal antibodyIndolesNeoplasm ProteinsnintedanibPaclitaxel

Identifiers

PMID30166402
PMCPMC6215503

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.