Evidence map›Paper›PMID 30166342›Full record

ArticleThe Journal of biological chemistry2018

Heat shock protein 27 promotes cell cycle progression by down-regulating E2F transcription factor 4 and retinoblastoma family protein p130.

Ah-Mee Park, Ikuo Tsunoda, Osamu Yoshie

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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  11. Transforming activities of theHaematologica · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ah-Mee ParkFrom the Department of Microbiology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589-8511, Japan and ampk@med.kindai.ac.jp.ORCID 0000-0001-8453-3872
Ikuo TsunodaFrom the Department of Microbiology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589-8511, Japan and.ORCID 0000-0003-1798-714X
Osamu YoshieFrom the Department of Microbiology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589-8511, Japan and.
Kindai University · JPMiyagi University · JP

Funding

COBRE Center for Molecular and Tumor VirologyP30GM110703 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI SAPP, MARTIN · 2014 to 2018
$4.8M
NIGMS NIH HHS P30 GM110703
6 · The paper itself

Abstract

Heat shock protein 27 (HSP27) protects cells under stress. Here, we demonstrate that HSP27 also promotes cell cycle progression of MRC-5 human lung fibroblast cells. Serum starvation for 24 h induced G

Indexed as

Cell CycleCell Line, TumorCell ProliferationCellular SenescenceDown-RegulationE2F4 Transcription FactorFibroblastsG2 PhaseGene SilencingHeat-Shock ProteinsHSP27 Heat-Shock ProteinsHumansLungMolecular ChaperonesOxygenRetinoblastoma-Like Protein p130E2F4 protein, humanE2F4 Transcription FactorHeat-Shock ProteinsHSP27 Heat-Shock ProteinsHSPB1 protein, humanMolecular ChaperonesOxygenRBL2 protein, humanRetinoblastoma-Like Protein p130RNA, Small InterferingTP53 protein, humanTumor Suppressor Protein p53cell cyclecell proliferationcellular senescencecyclin A2cyclin B1cyclin B2E2F transcription factorHSPB1small heat shock protein (sHsp)transcription repressor

Identifiers

PMID30166342
PMCPMC6187643
OpenAlexW2889491306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.