Evidence map›Paper›PMID 30165982›Full record

ArticleJournal of the American College of Cardiology2018

Declining Lung Function and Cardiovascular Risk: The ARIC Study.

Odilson M Silvestre, Wilson Nadruz, Gabriela Querejeta Roca, Brian Claggett, Scott D Solomon, Maria C Mirabelli, Stephanie J London, Laura R Loehr, Amil M Shah

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Journal of the American College of Cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 136 citations in OpenAlex.

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  15. Is There any Correlation Between Pulmonary and Coronary Involvement in Diabetic Patients?International journal of endocrinology and metabolism · 2025
    Article
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Odilson M SilvestreDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Department of Internal Medicine, Federal University of Acre, Rio Branco, Acre, Brazil.
Wilson NadruzDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Department of Internal Medicine, University of Campinas, Campinas, Brazil.
Gabriela Querejeta RocaDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Brian ClaggettDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Scott D SolomonDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Maria C MirabelliRollins School of Public Health, Emory University, Atlanta, Georgia.
Stephanie J LondonNational Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina.
Laura R LoehrGillings School of Public Health, University of North Carolina, Chapel Hill, North Carolina.
Amil M ShahDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: ashah11@partners.org.
Brigham and Women's Hospital · USEmory University · USNational Institutes of Health · USUniversity of North Carolina at Chapel Hill · US

Funding

Mapping the Progression to HFpEF in the Elderly through Longitudinal Changes in Cardiac FunctionR01HL135008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Amil M Shah · 2017 to 2026
$11.5M
Genetics and Environment in Adult Respiratory, Allergic and Cardiac diseaseZIAES043012 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.4M
Systolic & diastolic dysfunction in heart failure and preserved ejection fractionK08HL116792 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAH, AMIL M · 2013 to 2017
$735k
Genetic /Environment Factors In Nonmalignant Resp DisZ01ES043012 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE JOAN · 1999 to 2008
$340k
Intramural NIH HHS Z01 ES043012NHLBI NIH HHS K08 HL116792NHLBI NIH HHS R01 HL135008
6 · The paper itself

Abstract

backgroundPulmonary dysfunction predicts incident cardiovascular disease (CVD).

objectivesThe purpose of this study was to evaluate whether longitudinal decline in lung function is associated with incident heart failure (HF), coronary heart disease (CHD), and stroke.

methodsAmong 10,351 participants in the ARIC (Atherosclerosis Risk In Communities) study free of CVD, rapid lung function decline was defined as the greatest quartile (n = 2,585) of decline in either forced expiratory volume in 1 s (FEV

resultsThe mean age was 54 ± 6 years, 56% were women, and 81% were white. At 17 ± 6 years of follow-up, HF occurred in 14%, CHD 11%, stroke 6%, and the composite in 24%. Rapid decline in FEV

conclusionsA rapid decline in lung function, assessed by serial spirometry, is associated with a higher incidence of subsequent CVD, particularly incident HF.

Indexed as

Age FactorsBlood PressureCoronary DiseaseC-Reactive ProteinFemaleFollow-Up StudiesForced Expiratory VolumeHeart FailureHeart RateHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsRisk AssessmentSpirometryC-Reactive ProteinNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)cardiovascular diseaseFEV(1)FVCheart failurelung function

Identifiers

PMID30165982
PMCPMC6121739
OpenAlexW2888816123

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.