ArticleGenome medicine2018
Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq).
Article in Genome medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Mapping 25 years of research on gut microbiota and antibiotic resistance: bibliometric insights and future directions.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Genomic surveillance of vancomycin-resistant Enterococcus faecium: a study on Resistome, Plasmidome, and mobilome profiling.Current genetics · 2025Article
- High-throughput targeted amplicon screening tool for characterizing intrahost diversity inMicrobial genomics · 2025Article
- Ampicillin-controlled glucose metabolism manipulates the transition from tolerance to resistance in bacteria.Science advances · 2023Article
- Multiplexed Target Enrichment Enables Efficient and In-Depth Analysis of Antimicrobial Resistome in Metagenomes.Microbiology spectrum · 2022Article
- Mechanism-Based Approach to New Antibiotic Producers Screening among Actinomycetes in the Course of the Citizen Science Project.Antibiotics (Basel, Switzerland) · 2022Article
- Article
- Machine Learning Prediction of Resistance to Subinhibitory Antimicrobial Concentrations from Escherichia coli Genomes.mSystems · 2021Article
- The future of antibiotics begins with discovering new combinations.Annals of the New York Academy of Sciences · 2021Review
- Phenotypic and genotypic antimicrobial resistance patterns of Escherichia coli and Klebsiella isolated from dairy farm milk, farm slurry and water in Punjab, India.Environmental science and pollution research international · 2021Article
- Genomic Insights Into Last-Line Antimicrobial Resistance in Multidrug-ResistantFrontiers in microbiology · 2021Review
- Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches.Scientific reports · 2020Article
- Article
- Innovative and rapid antimicrobial susceptibility testing systems.Nature reviews. Microbiology · 2020Review
- Using genomics to understand meticillin- and vancomycin-resistantMicrobial genomics · 2020Review
- Unstable chromosome rearrangements inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa.Angewandte Chemie (International ed. in English) · 2019Article
- Genome-Based Prediction of Bacterial Antibiotic Resistance.Journal of clinical microbiology · 2019Review
- Indexed variation graphs for efficient and accurate resistome profiling.Bioinformatics (Oxford, England) · 2018Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
Mutation acquisition is a major mechanism of bacterial antibiotic resistance that remains insufficiently characterised. Here we present RM-seq, a new amplicon-based deep sequencing workflow based on a molecular barcoding technique adapted from Low Error Amplicon sequencing (LEA-seq). RM-seq allows detection and functional assessment of mutational resistance at high throughput from mixed bacterial populations. The sensitive detection of very low-frequency resistant sub-populations permits characterisation of antibiotic-linked mutational repertoires in vitro and detection of rare resistant populations during infections. Accurate quantification of resistance mutations enables phenotypic screening of mutations conferring pleiotropic phenotypes such as in vivo persistence, collateral sensitivity or cross-resistance. RM-seq will facilitate comprehensive detection, characterisation and surveillance of resistant bacterial populations ( https://github.com/rguerillot/RM-seq ).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.