ArticleArthritis research & therapy2018
Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis.
Article in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Crohn's and bones: assessing bone microarchitecture using high-resolution peripheral quantitative computed tomography.JBMR plus · 2026Article
- Increased Osteocyte Lacunae Size and Organic Matrix Pyridinoline Content in Transiliac Bone from Patients with Axial Spondyloarthritis (axSpA).Calcified tissue international · 2025Article
- [Systemic versus local demineralization in rheumatoid arthritis : Insights into the bone].Zeitschrift fur Rheumatologie · 2025Review
- Unconventional Imaging Methods in Psoriatic Arthritis.Current rheumatology reports · 2025Review
- Low Bone Turnover, Mineralization Impairment, and Cortical Alterations in Patients with Axial Spondyloarthritis: A Histomorphometric Study.Calcified tissue international · 2025Article
- Osteoimmunology of Spondyloarthritis.International journal of molecular sciences · 2023Review
- How Has Molecular Biology Enhanced Our Undertaking of axSpA and Its Management.Current rheumatology reports · 2023Review
- Association Between SPARC Polymorphisms and Ankylosing Spondylitis and Its mRNA and Protein Expression in a Chinese Han Population: A Case-Control Study.International journal of general medicine · 2023Article
- Effects of targeted therapies on bone in rheumatic and musculoskeletal diseases.Nature reviews. Rheumatology · 2022Review
- Bone Involvement in Patients with Spondyloarthropathies.Calcified tissue international · 2022Review
- Factors associated with changes in volumetric bone mineral density and cortical area in men with ankylosing spondylitis: a 5-year prospective study using HRpQCT.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Spatio-Temporal Bone Remodeling after Hematopoietic Stem Cell Transplantation.International journal of molecular sciences · 2020Article
- Enthesitis in psoriatic arthritis (Part 1): pathophysiology.Rheumatology (Oxford, England) · 2020Review
- A Contemporary View of the Diagnosis of Osteoporosis in Patients With Axial Spondyloarthritis.Frontiers in medicine · 2020Review
- Calcium physiology, metabolism and supplementation: a glance at patients with ankylosing spondylitis.Reumatologia · 2020Review
- Osteoporosis in Rheumatic Diseases.International journal of molecular sciences · 2019Review
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13 authors.
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Abstract
backgroundIn the present study, we investigated bone geometry, microstructure, and volumetric bone mineral density (vBMD) in a cohort of patients with nonradiographic axial spondyloarthritis (nr-axSpA) in order to define the early bone changes occurring in axial spondyloarthritis (axSpA) and to define potential factors for deterioration of bone microstructure.
methodsPatients with axSpA (n = 107) and healthy control subjects (n = 50) of similar age and sex were assessed for geometric, volumetric, and microstructural parameters of bone using high-resolution peripheral quantitative computed tomography (HR-pQCT) at the radius. Additionally, demographic and disease-specific characteristics of patients with axSpA were recorded.
resultsPatients with nr-axSpA and control subjects were comparable in age, sex, and body mass index. Geometric and microstructural analysis by HR-pQCT revealed a significantly reduced cortical area (p = 0.022) and cortical thickness (p = 0.006) in patients with nr-axSpA compared with control subjects. Total and cortical vBMD were significantly reduced in patients with nr-axSpA (p = 0.042 and p = 0.007, respectively), whereas there was no difference in trabecular vBMD. Patients with a short disease duration (< 2 years; n = 46) also showed significant reduction of cortical thickness and cortical area compared with control subjects. Patients with disease duration > 2 years (n = 55) additionally developed a decrease of cortical and total vBMD. Multiple regression models identified male sex to be associated with lower cortical vBMD and female sex to be associated with lower trabecular vBMD.
conclusionsBone microstructure in patients with nr-axSpA is characterized primarily by deterioration of cortical bone. Cortical bone loss starts early and is evident within the first 2 years of the disease.
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