Evidence map›Paper›PMID 30165888›Full record

ArticleBMC research notes2018

Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden.

Mikael Lilja, Micael Widerström, Johan Lindh

Abstract read
In one paragraph

Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Retrospective case-case study investigation of a significant increase inEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  3. Genetic diversity ofCurrent research in parasitology & vector-borne diseases · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Protozoan infections are under-recognized in Swedish patients with gastrointestinal symptoms.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  10. Microorganisms · 2020
    Review
  11. Health sequelae of human cryptosporidiosis-a 12-month prospective follow-up study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mikael LiljaDepartment of Public Health and Clinical Medicine, Unit of Clinical Research Center-Östersund, Umeå University, Umeå, Sweden.
Micael WiderströmDepartment of Clinical Microbiology, Unit of Communicable Disease Control and Prevention-Östersund, Umeå University, Umeå, Sweden.
Johan LindhDepartment of Cell and Molecular Biology, Microbiology, Uppsala University, Box 256, 751 05, Uppsala, Sweden. johan.lindh@icm.uu.se.ORCID http://orcid.org/0000-0002-8025-6078

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn 2010-2011, a large waterborne outbreak of Cryptosporidium hominis affected the city of Östersund in Sweden. Previous findings had suggested that gastrointestinal symptoms can persist for up to 11 months after the initial infection. Here we investigated whether the parasite could cause sequelae in infected individuals up to 28 months after the outbreak. We compared cases linked to the outbreak and the previous follow-up study with non-cases regarding symptoms present up to 28 months after the initial infection. We investigated whether cases were more likely to report a list of symptoms at follow-up compared to non-cases, calculating odds ratio and 95% confidence interval obtained through logistic regression.

resultsA total of 559 individuals (215 cases) were included in the study. Forty-eight percent of the outbreak cases reported symptoms at follow-up. Compared to non-cases, cases were more likely to report watery diarrhea, diarrhea, abdominal pain, fatigue, nausea, headache, or joint stiffness/pain/discomfort at follow-up after adjusting for age and sex. Our findings suggest that gastrointestinal symptoms and joint pain can persist several years after the initial Cryptosporidium infection and should be regarded as a potential cause of unexplained gastrointestinal symptoms or joint pain in people who have had this infection.

Indexed as

AdolescentAdultAgedAnimalsChildChild, PreschoolCryptosporidiosisCryptosporidiumDiarrheaDisease OutbreaksFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesCryptosporidiumDiarrheaSequelae

Identifiers

PMID30165888
PMCPMC6117891

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.