ArticleJournal of translational medicine2018
Invasive non-typhoidal Salmonella in sickle cell disease in Africa: is increased gut permeability the missing link?
Article in Journal of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Infections in sickle cell disease.Haematologica · 2025Review
- Review
- Association of Sickle Cell Disease, Malaria and HIV in Multi Drug Resistant Invasive Non-typhoidalEast Africa science · 2024Article
- The role of tissue resident memory CD4 T cells in Salmonella infection: Implications for future vaccines.Vaccine · 2023Review
- Intestinal barrier functions in hematologic and oncologic diseases.Journal of translational medicine · 2023Review
- Antimicrobial resistance and virulence genes of invasiveSAGE open medicine · 2023Article
- High-throughput sequencing-based metagenomic and transcriptomic analysis of intestine in piglets infected withJournal of animal science and technology · 2022Article
- L-glutamine for sickle cell disease: more than reducing redox.Annals of hematology · 2022Review
- Malaria disrupts the rhesus macaque gut microbiome.Frontiers in cellular and infection microbiology · 2022Article
- Geographical distribution of risk factors for invasive non-typhoidal Salmonella at the subnational boundary level in sub-Saharan Africa.BMC infectious diseases · 2021Article
- Undernutrition: a major but potentially preventable cause of poor outcomes in children living with sickle cell disease in Africa.BMC medicine · 2021Article
- High genetic similarity between non-typhoidal Salmonella isolated from paired blood and stool samples of children in the Democratic Republic of the Congo.PLoS neglected tropical diseases · 2020Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-typhoidal Salmonella usually induces self-limiting gastroenteritis. However, in many parts of Africa, especially in individuals who are malnourished, infected with malaria, or have sickle cell disease, the organism causes serious and potentially fatal systemic infections. Since the portal of entry of non-typhoidal Salmonella into the systemic circulation is by way of the intestine, we argue that an increased gut permeability plays a vital role in the initiation of invasive non-typhoidal Salmonella in these patients. Here, we will appraise the evidence supporting a breach in the intestinal barrier and propose the mechanisms for the increased risks for invasive non-typhoidal Salmonella infections in these individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.