ArticleJournal of intensive care medicine2020
Sequential Organ Failure Assessment Component Score Prediction of In-hospital Mortality From Sepsis.
Article in Journal of intensive care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Inter-clinician diagnostic agreement of shock etiology: a multicenter observational study.Health information science and systems · 2026Article
- The new SOFA for sepsis identification and mortality prediction: a multicenter cohort study.Journal of intensive care · 2026Article
- Performance of sequential organ failure assessment 1 versus 2 for sepsis identification in patients with suspected infection: a multicenter retrospective cohort study.Critical care (London, England) · 2026Article
- Article
- AKI-twinX: explainable organ structured digital twin for sepsis AKI trajectory forecasting.medRxiv : the preprint server for health sciences · 2026Article
- Association between preoperative vasoactive inotropic score and clinical outcomes in severe pneumonia patients with sepsis undergoing extracorporeal membrane oxygenation: an analysis from the Chinese Society of ExtraCorporeal Life Support (CSECLS) Registry.European journal of medical research · 2026Article
- Article
- Article
- Correlations of three scoring systems with the prognosis of patients with liver cirrhosis complicated with sepsis syndrome.World journal of gastrointestinal surgery · 2025Article
- Prognostic value of the Geriatric Nutritional Risk Index in sepsis-associated acute kidney injury: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Assessment of organ failure in sepsis patients in the emergency department: clinical evaluation, Sequential Organ Failure Assessment (SOFA) score, and future perspectives.Clinical and experimental emergency medicine · 2024Article
- Article
- Associations Between Volume of Early Intravenous Fluid and Hospital Outcomes in Septic Patients With and Without Heart Failure: A Retrospective Cohort Study.Critical care explorations · 2024Article
- Association between white blood cell-to-haemoglobin ratio and 30 day mortality in heart failure in intensive care unit.ESC heart failure · 2024Article
- Analyzing how the components of the SOFA score change over time in their contribution to mortality.Critical care science · 2024Article
- Racial disparities in septic shock mortality: a retrospective cohort study.Lancet regional health. Americas · 2024Article
- Modified Cardiovascular Sequential Organ Failure Assessment Score in Sepsis: External Validation in Intensive Care Unit Patients.Journal of Korean medical science · 2023Observational
- Prognostic Accuracy of SpOThe western journal of emergency medicine · 2023Article
- Validity of the total SOFA score in patients ≥ 80 years old acutely admitted to intensive care units: a post-hoc analysis of the VIP2 prospective, international cohort study.Annals of intensive care · 2023Article
- Prognostic accuracy of initial and 24-h maximum SOFA scores of septic shock patients in the emergency department.Heliyon · 2023Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesEarly organ dysfunction in sepsis confers a high risk of in-hospital mortality, but the relative contribution of specific types of organ failure to overall mortality is unclear. The objective of this study was to assess the predictive ability of individual types of organ failure to in-hospital mortality or prolonged intensive care.
methodsRetrospective cohort study of adult emergency department patients with sepsis from October 1, 2013, to November 10, 2015. Multivariable regression was used to assess the odds ratios of individual organ failure types for the outcomes of in-hospital death (primary) and in-hospital death or ICU stay ≥ 3 days (secondary).
resultsOf 2796 patients, 283 (10%) experienced in-hospital mortality, and 748 (27%) experienced in-hospital mortality or an ICU stay ≥ 3 days. The following components of Sequential Organ Failure Assessment (SOFA) score were most predictive of in-hospital mortality (descending order): coagulation (odds ratio [OR]: 1.60, 95% confidence interval [CI]: 1.32-1.93), hepatic (1.58, 95% CI: 1.32-1.90), respiratory (OR: 1.33, 95% CI: 1.21-1.47), neurologic (OR: 1.20, 95% CI: 1.07-1.35), renal (OR: 1.14, 95% CI: 1.02-1.27), and cardiovascular (OR: 1.13, 95% CI: 1.01-1.25). For mortality or ICU stay ≥3 days, the most predictive SOFA components were respiratory (OR: 1.97, 95% CI: 1.79-2.16), neurologic (OR: 1.72, 95% CI: 1.54-1.92), cardiovascular (OR: 1.38, 95% CI: 1.23-1.54), coagulation (OR: 1.31, 95% CI: 1.10-1.55), and renal (OR: 1.19, 95% CI: 1.08-1.30) while hepatic SOFA (OR: 1.16, 95% CI: 0.98-1.37) did not reach statistical significance (
conclusionIn this retrospective study, SOFA score components demonstrated varying predictive abilities for mortality in sepsis. Elevated coagulation or hepatic SOFA scores were most predictive of in-hospital death, while an elevated respiratory SOFA was most predictive of death or ICU stay >3 days.
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