ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2020
The association of calcium oxalate deposition in kidney allografts with graft and patient survival.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Oxalate deposition in renal allograft biopsies within 3 months after transplantation is associated with allograft dysfunction.PloS one · 2019Trial
- Clinical and Histopathologic Spectrum of Primary Nonfunction in Renal Allografts.Kidney international reports · 2026Article
- Contributions of the anion exchangers SLC26A1, SLC26A2, SLC26A3, and SLC26A6 to intestinal oxalate transport in human Caco2-BBE cells.Physiological reports · 2026Article
- Pre-transplant residual diuresis and oxalic acid concentration influence kidney graft survival.PloS one · 2025Article
- Delayed Graft Function After Kidney Transplantation: The Role of Residual Diuresis and Waste Products, as Oxalic Acid and Its Precursors.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Sel1-like proteins and peptides are the majorAmerican journal of physiology. Cell physiology · 2023Article
- Prospective Assessment of the Prevalence of Enter Hyperoxalosis in Kidney Transplant Candidates.Transplantation direct · 2023Article
- Oxalate homeostasis.Nature reviews. Nephrology · 2023Review
- Detection and localization of calcium oxalate in kidney using synchrotron deep ultraviolet fluorescence microscopy.Journal of synchrotron radiation · 2022Article
- Incidence and Importance of Calcium Deposition in Kidney Biopsy Specimens.American journal of nephrology · 2022Article
- Posttransplant recurrence of calcium oxalate crystals in patients with primary hyperoxaluria: Incidence, risk factors, and effect on renal allograft function.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- High Plasma Oxalate Levels Early After Kidney Transplantation Are Associated With Impaired Long-Term Outcomes.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Pilot study of reloxaliase in patients with severe enteric hyperoxaluria and hyperoxalemia.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Article
- Author Reply to Comment on "Assessment of Plasma Oxalate Concentration in Patients With CKD" by OkaKidney international reports · 2021Article
- Two Faces of Vitamin C in Hemodialysis Patients: Relation to Oxidative Stress and Inflammation.Nutrients · 2021Review
- Assessment of Plasma Oxalate Concentration in Patients With CKD.Kidney international reports · 2020Article
- Dietary Oxalate Intake and Kidney Outcomes.Nutrients · 2020Review
- Enteric Oxalate Secretion Mediated by Slc26a6 Defends against Hyperoxalemia in Murine Models of Chronic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2020Article
- Association of Urinary Oxalate Excretion With the Risk of Chronic Kidney Disease Progression.JAMA internal medicine · 2019Observational
- Accelerated Oxalosis Contributing to Delayed Graft Function after Renal Transplantation.Case reports in transplantation · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWhether calcium oxalate (CaOx) deposition in kidney allografts following transplantation (Tx) adversely affects patient outcomes is uncertain, as are its associated risk factors.
methodsWe performed a retrospective cohort study of patients who had kidney allograft biopsies performed within 3 months of Tx at Brigham and Women's Hospital and examined the association of CaOx deposition with the composite outcome of death or graft failure within 5 years.
resultsBiopsies from 67 of 346 patients (19.4%) had CaOx deposition. In a multivariable logistic regression model, higher serum creatinine [odds ratio (OR) = 1.28 per mg/dL, 95% confidence interval (CI) 1.15-1.43], longer time on dialysis (OR = 1.11 per additional year, 95% CI 1.01-1.23) and diabetes (OR = 2.26, 95% CI 1.09-4.66) were found to be independently associated with CaOx deposition. CaOx deposition was strongly associated with delayed graft function (DGF; OR = 11.31, 95% CI 5.97-21.40), and with increased hazard of the composite outcome after adjusting for black recipient race, donor type, time on dialysis before Tx, diabetes and borderline or acute rejection (hazard ratio 1.90, 95% CI 1.13-3.20).
conclusionsCaOx deposition is common in allografts with poor function and portends worse outcomes up to 5 years after Tx. The extent to which CaOx deposition may contribute to versus result from DGF, however, cannot be determined based on our retrospective and observational data. Future studies should examine whether reducing plasma and urine oxalate prevents CaOx deposition in the newly transplanted kidney and whether this has an effect on clinical outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.