Evidence map›Paper›PMID 30165648›Full record

ArticleThe Journal of infectious diseases2019

Food Insecurity Is Associated With Inflammation Among Women Living With HIV.

Anna M Leddy, Annelys Roque, Lila A Sheira, Edward A Frongillo, Alan L Landay, Adebola A Adedimeji, Tracey E Wilson, Daniel Merenstein, Eryka Wentz, Adaora A Adimora and 7 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anna M LeddyDivision of Prevention Science, Center for AIDS Prevention Studies, University of California San Francisco.
Annelys RoqueDepartment of Medicine, University of California San Francisco.
Lila A SheiraDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco.
Edward A FrongilloDepartment of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, Columbia.
Alan L LandayDepartment of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois.
Adebola A AdedimejiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
Tracey E WilsonDepartment of Community Health Sciences, School of Public Health, SUNY Downstate, Brooklyn, New York.
Daniel MerensteinDepartment of Medicine, Georgetown University Medical Center, Washington, District of Columbia.
Eryka WentzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Adaora A AdimoraSchool of Medicine, University of North Carolina at Chapel Hill, North Carolina.
Igho OfotokunDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Lisa R MetschDepartment of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York.
Mardge H CohenDivision of General Internal Medicine, Cook County Health and Hospital System, Chicago, Illinois.
Phyllis C TienDepartment of Medicine, University of California San Francisco.
Janet M TuranDepartment of Health Care Organization and Policy, School of Public Health.
Bulent TuranDepartment of Psychology, University of Alabama at Birmingham.
Sheri D WeiserDivision of Prevention Science, Center for AIDS Prevention Studies, University of California San Francisco.

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sheri Ann Lippman · 2001 to 2026
$57.4M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000454NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01 HL146194NHLBI NIH HHS U01 HL146203NHLBI NIH HHS U01 HL146205NIAID NIH HHS K24 AI108516NIAID NIH HHS K24 AI134326NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI050410NIAID NIH HHS R38 AI140299NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01 AI103390NIAID NIH HHS U01 AI103397NIAID NIH HHS U01 AI103401NIAID NIH HHS U01 AI103408NIA NIH HHS R21 AG059505NIA NIH HHS U54 AG062334NICHD NIH HHS U01 HD032632NIMH NIH HHS P30 MH062246NIMH NIH HHS R01 MH095683NIMH NIH HHS R01 MH104114NIMH NIH HHS T32 MH019105
6 · The paper itself

Abstract

Background: Chronic inflammation is associated with AIDS-defining and non-AIDS-defining conditions. Limited research has considered how food insecurity influences chronic inflammation among people living with human immunodeficiency virus (HIV). We examined whether food insecurity was associated with higher levels of inflammation among women living with HIV (WWH) in the United States. Methods: We analyzed cross-sectional data collected in 2015 from 421 participants on antiretroviral therapy from the Women's Interagency HIV Study. The exposure was any food insecurity. The outcome was inflammation, measured by proinflammatory cytokine interleukin-6 (IL-6) and tumor necroses factor receptor 1 (TNFR1) levels. We conducted multivariable linear regressions, adjusting for sociodemographic, clinical, and nutritional factors. Results: Nearly one-third of participants (31%) were food insecure and 79% were virally suppressed (<20 copies/mL). In adjusted analyses, food insecurity was associated with 1.23 times the level of IL-6 (95% confidence interval [CI], 1.06-1.44) and 1.13 times the level of TNFR1 (95% CI, 1.05-1.21). Findings did not differ by HIV control (virally suppressed with CD4 counts ≥500 cells/mm3 or not) in adjusted stratified analyses. Conclusion: Food insecurity was associated with elevated inflammation among WWH regardless of HIV control. Findings support the need for programs that address food insecurity among WWH.

Indexed as

AdultBody Mass IndexCross-Sectional StudiesFemaleFood SupplyHIV InfectionsHumansInflammationInterleukin-6Linear ModelsMiddle AgedMultivariate AnalysisReceptors, Tumor Necrosis Factor, Type IUnited StatesInterleukin-6Receptors, Tumor Necrosis Factor, Type I

Identifiers

PMID30165648
PMCPMC6325349

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.