Evidence map›Paper›PMID 30165516›Full record

ArticleEuropean heart journal2018

2018 ESC/ESH Guidelines for the management of arterial hypertension.

Bryan Williams, Giuseppe Mancia, Wilko Spiering, Enrico Agabiti Rosei, Michel Azizi, Michel Burnier, Denis L Clement, Antonio Coca, Giovanni de Simone, Anna Dominiczak and 19 more

Erratum issued 22 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in European heart journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 22 registered trials, which are not on this map. Cited by 4,677 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4,677citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04055285 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Effect of Renal Denervation on Atrial Fibrillation

TypeinterventionalSponsorHippocration General HospitalRan2020 to 2022Enrolled30ConditionsArterial Hypertension, Atrial FibrillationArmsSympathetic Renal Denervation, Implantable Loop Recorder
NCT04190420 unknown statusnot on this map

The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Study

TypeobservationalSponsorKarolinska InstitutetRan2018 to 2025Enrolled310ConditionsHypertension, Heart Failure, Hypertensive Heart Disease, Diastolic Dysfunction
NCT04314557 completednot on this mapstarted 2019, after this paper: background citation

Renal Arterial Denervation in Sympathetic Dysautonomia: RANSOM REGISTRY

Typeobservational_patient_registrySponsorSt Carlos Hospital, Madrid, SpainRan2019 to 2025Enrolled13ConditionsHypertension, Renal Denervation, Increased Variability, Blood Pressure DisordersArmsRenal denervation
NCT04746118 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effectiveness of Nutritional Intervention Alone or Associated With Other Non-pharmacological Interventions in Controlling Hypertension and Reducing Cardiovascular Risk - Randomized Clinical Trial

TypeinterventionalSponsorHospital Universitário Clementino Fraga FilhoRan2021 to 2023Enrolled240ConditionsHypertensionArmsDIET CHANGE, PHYSICAL ACTIVITY, INTEGRATIVE PRACTICES
NCT04751292 completednot on this mapstarted 2021, after this paper: background citation

HIGH Altitude CArdiovascular REsearch Latin America Population Study

TypeobservationalSponsorIstituto Auxologico ItalianoRan2021 to 2023Enrolled937ConditionsHypertension, Cardiovascular Risk Factor, Altitude Hypoxia, Altitude SicknessArmsExposure to high altitude
NCT05052151 nacompletednot on this mapstarted 2021, after this paper: background citation

Hemodynamic Effects of Low vs. High Dialysate Temperature or Bicarbonate Concentration in Chronic Hemodialysis Patients

TypeinterventionalSponsorUniversity of AarhusRan2021 to 2022Enrolled16ConditionsEnd Stage Renal Disease on DialysisArmsLow dialysate temperature, High dialysate temperature, Low dialysate bicarbonate concentration, High dialysate bicarbonate concentration
NCT05140590 completednot on this mapstarted 2021, after this paper: background citation

Pharmacological Interactions Between Antihypertensive Regimens and Drugs Prescribed in the Emergency Department of the HGZ 51

Typeobservational_patient_registrySponsorInstituto Mexicano del Seguro SocialRan2021 to 2022Enrolled53ConditionsDrug Interactions, Hypertension
NCT05179343 nacompletednot on this mapstarted 2022, after this paper: background citation

Sham Controlled RCT Evaluating the Safety, Acceptability and Efficacy of Autonomic Neuromodulation Using Trans-cutaneous Vagal Stimulation in Uncontrolled Hypertensive Patients: a Pilot Study

TypeinterventionalSponsorQueen Mary University of LondonRan2022 to 2025Enrolled63ConditionsUncontrolled Hypertension, High Blood PressureArmsActive AffeX-CT device, Sham AffeX-CT device
NCT05347823 unknown statusnot on this mapstarted 2022, after this paper: background citation

Study of Adherence to Antihypertensive Drugs and Statins in the Population of Subjects With Hypertension Followed at SIIA Centers, Using an Innovative Monitoring Based on Hair Analysis

TypeobservationalSponsorAzienda Ospedaliera Universitaria Integrata VeronaRan2022 to 2023Enrolled200ConditionsArterial Hypertension, Dyslipidemias, Antihypertensive Drugs, StatinsArmsHair analysis for drug concentration
NCT05438446 phase2completednot on this mapstarted 2021, after this paper: background citation

Effect of Renal Denervation on Stress, Hypertension and Anxiety Management (ERSHAM Study) in Patients With Uncontrolled Hypertension

TypeinterventionalSponsorHippocration General HospitalRan2021 to 2026Enrolled60ConditionsHypertension Arterial, Anxiety, StressArmsEndovascular ultrasound renal denervation (Paradise renal denervation system, ReCor, CA, USA) (RDN)
NCT05580549 unknown statusnot on this mapstarted 2022, after this paper: background citation

Prevalence of Hazardous Alcohol Use in a Population With Hypertension in Primary Care Detected With PEth and AUDIT - Observational Cross-sectional Study

TypeobservationalSponsorRegion StockholmRan2022 to 2023Enrolled270ConditionsHypertension, Alcohol Drinking, Alcohol Use, UnspecifiedArmsAlcohol biomarker Phosphatidylethanol (PEth)
NCT05690997 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Intensive Blood Pressure Control on Cerebral Blood Flow and Cognition in Ischaemic Stroke Patients With Severe Cerebral Small Vessel Disease

TypeinterventionalSponsorThe University of Hong KongRan2023 to 2025Enrolled104ConditionsSmall Vessel Cerebrovascular Disease, StrokeArmsIntensive treatment, Standard treatment
NCT05844566 nacompletednot on this mapstarted 2023, after this paper: background citation

Implementation of a Decision Support System and Its Effect on Early Optimisation of Lipid-Lowering Therapies in Patients With Acute Coronary Syndrome: a Cluster Randomised Controlled Trial

TypeinterventionalSponsorImperial College LondonRan2023 to 2024Enrolled1,139ConditionsAcute Coronary Syndrome, Myocardial InfarctionArmsDecision Support System (DSS)
NCT05936892 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparative Effects of UE Aerobic and Resistance Training on Cardiorespiratory Fitness in Hypertensive Patients

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2023Enrolled40ConditionsBlood PressureArmsupper extremity aerobic training, upper extremity resistance training
NCT06141200 phase3unknown statusnot on this mapstarted 2024, after this paper: background citation

Efficacy and Safety of Roselle in Patients With Grade 1 Essential Hypertension: A Phase III, Randomized, Double-Blind, Double-Dummy, Active-Controlled Clinical Trial

TypeinterventionalSponsorNatural Wellness EgyptRan2024 to 2025Enrolled286ConditionsEssential HypertensionArmsNW Roselle, Captopril 25Mg Tab
NCT06208501 unknown statusnot on this mapstarted 2023, after this paper: background citation

The Predictive Role of Proteomics in Blood Pressure Response of Hypertensive Patients Undergoing Renal Denervation.

TypeobservationalSponsorHippocration General HospitalRan2023 to 2025Enrolled100ConditionsHypertension, Renal Denervation, ProteomicsArmsUrine sample for proteomic analysis, ABPM, OBPM
NCT06325800 recruitingnot on this mapstarted 2024, after this paper: background citation

Multimodal Vascular Phenotyping and Target-Organ Damage Using Vascular Imaging, Glyco-Oxidative Biomarkers, and Photoplethysmography in Adults at Increased Cardiovascular Risk: The GlycOxiTOD Observational Registry

Typeobservational_patient_registrySponsorComplejo Hospitalario Universitario de SantiagoRan2024 to 2035Enrolled1,000ConditionsHypertension, Target Organ Damage, Heart Disease Risk Factors, Vascular StiffnessArmsMultimodal Cardiovascular Phenotyping
NCT06444711 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

A Randomised Clinical Trial for OPTIMISation of Cardio-renal-metabolic-pulmonary Disease Guideline Adherence in High Risk Community Dwelling Individuals and Evaluation of Outcomes

TypeinterventionalSponsorUniversity of LeedsRan2025 to 2045Enrolled138ConditionsCardiovascular Diseases, Renal Disease, Metabolic Disease, Pulmonary DiseaseArmsNICE guidance
NCT06627920 completednot on this mapstarted 2024, after this paper: background citation

Validation of a Smartwatch for Blood Pressure Measurement

TypeobservationalSponsorEuropean University Miguel de CervantesRan2024 to 2024Enrolled101ConditionsBlood Pressure, Heart Rate, Oxygen SaturationArmsUse of the KC08 smartwatch, Beurer PO30 and Omron M7 BP monitor.
NCT06780865 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Protection of Renal Function by Antihypertensive Treatment in Patients with Chronic Kidney Disease and Isolated Nighttime Hypertension

TypeinterventionalSponsorShanghai Institute of HypertensionRan2025 to 2028Enrolled200ConditionsChronic Kidney Disease(CKD), Nocturnal HypertensionArmsAntihypertensive treatment with Arotinolol or Amlodipine or Clonidine, Placebo-controlled group
NCT07200856 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Impact of Nocturnal Blood Pressure Dipping on Ventricular Repolarization in Hypertensive Patients

Typeobservational_patient_registrySponsorAssiut UniversityRan2025 to 2027Enrolled140ConditionsHypertension, Blood Pressure Monitoring, Ambulatory, Circadian Rhythm, ElectrocardiographyArmsNocturnal Blood Pressure Dipping
NCT07370363 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Moderate-Intensity Continuous Exercise Versus Brisk Interval Exercise on Cardiometabolic Parameters and Sestrin-2 Levels in Hypertensive Obese Women: A Randomized Controlled Trial

TypeinterventionalSponsorHavva Talay ÇalışRan2026 to 2026Enrolled42ConditionsObesity, HypertensionArmsModerate-Intensity Continuous Exercise, Brisk Interval Exercise
3 · Its place in the literature

Who cites it

4,677 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Guideline
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  6. Efficacy and Safety of ARB-Based Combination Therapies for Treatment of Hypertension: A Systematic Review and Meta-analyses.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Pooled it
  7. Accelerated epigenetic age in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Pooled it
  8. Trial
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  17. Low-Dose Telmisartan/Amlodipine in Essential Hypertension: A Phase III Trial.Journal of clinical hypertension (Greenwich, Conn.) · 2026
    Trial
  18. Trial
  19. Trial
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4,617 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Bryan Williams
Giuseppe Mancia
Wilko Spiering
Enrico Agabiti Rosei
Michel Azizi
Michel Burnier
Denis L Clement
Antonio Coca
Giovanni de Simone
Anna Dominiczak
Thomas Kahan
Felix Mahfoud
Josep Redon
Luis Ruilope
Alberto Zanchetti
Mary Kerins
Sverre E Kjeldsen
Reinhold Kreutz
Stephane Laurent
Gregory Y H Lip
Richard McManus
Krzysztof Narkiewicz
Frank Ruschitzka
Roland E Schmieder
Evgeny Shlyakhto
Costas Tsioufis
Victor Aboyans
Ileana Desormais
ESC Scientific Document Group

Funding

Department of Health 12/01/52Department of Health IS-SPC-0514-10043Department of Health NIHR-RP-02-12-015Medical Research Council G9900264Medical Research Council MC_PC_13090
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 16 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.