Evidence map›Paper›PMID 30165482›Full record

ReviewFEMS yeast research2018

Mitochondria-cytosol-nucleus crosstalk: learning from Saccharomyces cerevisiae.

Nicoletta Guaragnella, Liam P Coyne, Xin Jie Chen, Sergio Giannattasio

Open access · bronzeAbstract readReview
In one paragraph

Review in FEMS yeast research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 68 citations in OpenAlex.

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  14. Inactivation ofInternational journal of molecular sciences · 2023
    Article
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  18. Mitochondrial Research: Yeast and Human Cells as Models.International journal of molecular sciences · 2022
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Nicoletta GuaragnellaInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies, CNR, Via Amendola 165/A, 70126 Bari, Italy.
Liam P CoyneDepartment of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
Xin Jie ChenDepartment of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
Sergio GiannattasioInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies, CNR, Via Amendola 165/A, 70126 Bari, Italy.
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies · ITSUNY Upstate Medical University · US

Funding

Mechanism of age-dependent neuromuscular degeneration caused by protein misfolding on the inner mitochondrial membraneF30AG060702 · NIA · UPSTATE MEDICAL UNIVERSITY · PI COYNE, LIAM PATRICK · 2018 to 2021
$201k
NIA NIH HHS F30 AG060702
6 · The paper itself

Abstract

Mitochondria are key cell organelles with a prominent role in both energetic metabolism and the maintenance of cellular homeostasis. Since mitochondria harbor their own genome, which encodes a limited number of proteins critical for oxidative phosphorylation and protein translation, their function and biogenesis strictly depend upon nuclear control. The yeast Saccharomyces cerevisiae has been a unique model for understanding mitochondrial DNA organization and inheritance as well as for deciphering the process of assembly of mitochondrial components. In the last three decades, yeast also provided a powerful tool for unveiling the communication network that coordinates the functions of the nucleus, the cytosol and mitochondria. This crosstalk regulates how cells respond to extra- and intracellular changes either to maintain cellular homeostasis or to activate cell death. This review is focused on the key pathways that mediate nucleus-cytosol-mitochondria communications through both transcriptional regulation and proteostatic signaling. We aim to highlight yeast that likely continues to serve as a productive model organism for mitochondrial research in the years to come.

Indexed as

Gene Regulatory NetworksStress, PhysiologicalCell NucleusCytosolMitochondriaSaccharomyces cerevisiae

Identifiers

PMID30165482
PMCPMC6110143
OpenAlexW2886049585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.