ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2019
Early-Life Adversity and Dysregulation of Adult Diurnal Cortisol Rhythm.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Blunted diurnal cortisol slope as a risk marker for 9-year executive function decline: amplification by daily stress and worry severity.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Adverse childhood experiences and learning engagement in medical students: the mediating role of negative emotions.BMC medical education · 2026Article
- Loneliness, positive social interactions, and diurnal cortisol among mid-to-later life adults in everyday life.Biological psychology · 2026Article
- A Community-Engaged Approach for Assessment of Cortisol Dynamic Range and Multilevel Chronic Stress in African Americans: FAITH! Heart Health+ Ancillary Study.Journal of participatory medicine · 2025Article
- Gambling, trauma, and the mind: a network analysis of online gambling and personal well-being.BMC psychology · 2025Article
- The National Study of Daily Experiences: Protocol for Assessments of Daily Stress, Well-Being, Health, and Salivary Biomarkers in a Longitudinal Cohort.JMIR research protocols · 2025Article
- Daily Stress and Cortisol Patterns in Midlife and Older Parents of Children With Developmental Disabilities.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Lifetime Stressor Severity and Diurnal Cortisol in Older African American Adults: A Comparison of Three Theoretical Models.Developmental psychobiology · 2025Article
- Leukocytes: Likely not the immune system's white knights in the wake of early life adversity.Brain, behavior, and immunity · 2024Article
- Genotypic variation in the promoter region of the CRH-248 gene interacts with early rearing experiences to disrupt the development of the HPA axis in infant rhesus macaques (Stress (Amsterdam, Netherlands) · 2024Article
- Article
- Early and recent exposure to adversity, TLR-4 stimulated inflammation, and diurnal cortisol in women with interstitial cystitis/bladder pain syndrome: A MAPP research network study.Brain, behavior, and immunity · 2023Article
- Childhood environment early life stress, caregiver warmth, and associations with the cortisol diurnal curve in adulthood: The coronary artery risk development in young adults (CARDIA) study.Psychoneuroendocrinology · 2023Article
- Advancing health equity through integrated biology and population health research: A community-based sample cortisol feasibility and exploratory study.Comprehensive psychoneuroendocrinology · 2022Article
- Diurnal dynamic range as index of dysregulation of system dynamics. A cortisol examplar using data from the Study of Midlife in the United States.Psychoneuroendocrinology · 2022Review
- Early Life Stress Alters Expression of Glucocorticoid Stress Response Genes and Trophic Factor Transcripts in the Rodent Basal Ganglia.International journal of molecular sciences · 2022Article
- Adverse childhood experiences amplify the longitudinal associations of adult daily stress and health.Child abuse & neglect · 2021Article
- Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework.Neuroscience and biobehavioral reviews · 2021Review
- Principal Component Analysis of the Social and Behavioral Rhythms Scale in elderly.Journal of public health research · 2021Article
- The mixed benefits of a stressor-free life.Emotion (Washington, D.C.) · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Objectives: Exposure to life stresses can lead to diminution in the capacity of stress response systems to mount a robust response to new challenges, with blunting of dynamic range-the spread between maximal attainable and minimal resting levels. We investigate the association between early-life adversity and the dynamic range of adult diurnal cortisol secretion. Method: In 35- to 86-year-old adults, cortisol assayed from 16 saliva samples over 4 consecutive days was used to compute diurnal dynamic range and area under the curve (AUC). Economic adversity in childhood was indexed by recalled parental education, family welfare dependence, and perceived financial status; and childhood social adversity by parental separation, death, and abuse. Results: Adjusted for age, gender, and race/ethnicity, both childhood adversities were strongly associated with smaller adult cortisol diurnal dynamic range, but not with AUC. The association with cortisol dynamic range was explained by adult social and economic variables. Discussion: Early-life adversity appears to leave a long-term imprint on cortisol secretion dynamics, reducing diurnal dynamic range without increasing total secretion. This points to the importance of examining the adaptation capacity of physiological systems when studying the impact of early-life and chronic stresses on adult health.
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Registered trials
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