ArticlePloS one2018
The role of kidney transplantation and phosphate binder use in vitamin K status.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Characterization of Load Components in Resistance Training Programs for Kidney Transplant Recipients: A Scoping Review.Sports (Basel, Switzerland) · 2025Review
- Vitamin K2 in Health and Disease: A Clinical Perspective.Foods (Basel, Switzerland) · 2024Review
- The Role of Vitamin K in CKD-MBD.Current osteoporosis reports · 2022Review
- Treatment of Vitamin K Deficiency in Hemodialysis Patients - A Pilot Study Comparing Menaquinone-7 Tablets and a Vitamin K Rich Diet.International journal of nephrology and renovascular disease · 2022Article
- Interplay between gut microbiota, bone health and vascular calcification in chronic kidney disease.European journal of clinical investigation · 2021Review
- Vitamin K in CKD Bone Disorders.Calcified tissue international · 2021Review
- Vitamin K and D Supplementation and Bone Health in Chronic Kidney Disease-Apart or Together?Nutrients · 2021Review
- Vitamin K and Kidney Transplantation.Nutrients · 2020Review
- Phosphate binders in chronic kidney disease: an updated narrative review of recent data.Journal of nephrology · 2020Review
- Current Therapy in CKD Patients Can Affect Vitamin K Status.Nutrients · 2020Review
- Observational
- Review
- Vitamin K effects in human health: new insights beyond bone and cardiovascular health.Journal of nephrology · 2020Review
- Review
- Vitamin K Dependent Proteins in Kidney Disease.International journal of molecular sciences · 2019Review
- Vitamin K in Chronic Kidney Disease.Nutrients · 2019Review
- The Bone-Vasculature Axis: Calcium Supplementation and the Role of Vitamin K.Frontiers in cardiovascular medicine · 2019Review
- Coronary Artery Calcification in Hemodialysis and Peritoneal Dialysis.American journal of nephrology · 2018Observational
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular disease is the leading cause of death in end-stage renal disease and is strongly associated with vascular calcification. Both kidney transplantation and phosphate binders may lower the risk of vascular calcification. Vascular calcification is actively inhibited by vitamin-K-dependent matrix γ-carboxyglutamic acid protein (MGP). Whether kidney transplantation or phosphate binders affect vitamin K status is unknown. Therefore, we studied the influence of kidney transplantation and phosphate binder use on vitamin K status.
methodsWe measured plasma desphospho-uncarboxylated MGP (dp-ucMGP), a marker reflecting low vitamin K status, in a cross-sectional study of patients on hemodialysis (n = 82), peritoneal dialysis (n = 31) or who recently received a kidney transplantation (n = 36). By medication inventory, we assessed phosphate binder use. With linear regression, we assessed the influence of kidney transplantation and phosphate binder use on natural-log-transformed dp-ucMGP, adjusting for potential confounders.
resultsMean age of patients was 52±13 years; 102 (68%) were male. Dp-ucMGP levels were significantly lower in kidney transplant recipients (median 689 pmol/L) compared to patients on dialysis (median 1537 pmol/L, p<0.001). Eighty-nine patients on dialysis used phosphate binders. Using any phosphate binder was not associated with dp-ucMGP levels (median 1637 pmol/L, p = 0.09) compared to no phosphate binders (median 1142 pmol/L). Twenty-six patients used sevelamer monotherapy, which was associated with higher dp-ucMGP levels (median 1740 pmol/L, p = 0.04) after adjusting for age, sex and vitamin K antagonist use.
conclusionsRecent kidney transplantation is associated with lower dp-ucMGP levels suggesting improved vitamin K status after transplantation. Sevelamer monotherapy is associated with higher dp-ucMGP levels suggesting worsening of vitamin K status. Both findings warrant more attention to vitamin K status in patients on dialysis, as vitamin K is necessary for protection against vascular calcification.
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