Evidence map›Paper›PMID 30161157›Full record

ArticlePloS one2018

Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury.

Sabrina Duranti, Valentina Vivo, Irene Zini, Christian Milani, Marta Mangifesta, Rosaria Anzalone, Leonardo Mancabelli, Alice Viappiani, Anna Maria Cantoni, Elisabetta Barocelli and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Chronic mesenteric ischemia-induced intestinal dysbiosis resolved after revascularization.Journal of vascular surgery cases and innovative techniques · 2023
    Article
  8. Review
  9. Article
  10. Association of Gut Microbiota With Intestinal Ischemia/Reperfusion Injury.Frontiers in cellular and infection microbiology · 2022
    Review
  11. Article
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Sabrina DurantiLaboratory of Probiogenomics, Department of Chemical Sciences, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.ORCID 0000-0002-7724-5669
Valentina VivoFood and Drug Department, University of Parma, Parma, Italy.
Irene ZiniFood and Drug Department, University of Parma, Parma, Italy.
Christian MilaniLaboratory of Probiogenomics, Department of Chemical Sciences, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
Marta MangifestaGenProbio srl, Parma, Italy.
Rosaria AnzaloneLaboratory of Probiogenomics, Department of Chemical Sciences, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
Leonardo MancabelliLaboratory of Probiogenomics, Department of Chemical Sciences, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
Alice ViappianiLaboratory of Probiogenomics, Department of Chemical Sciences, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
Anna Maria CantoniDepartment of Veterinary Sciences, University of Parma, Parma, Italy.
Elisabetta BarocelliLaboratory of Probiogenomics, Department of Chemical Sciences, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
Douwe van SinderenAPC Microbiome Institute and School of Microbiology, Bioscience Institute, National University of Ireland, Cork, Ireland.
Simona BertoniFood and Drug Department, University of Parma, Parma, Italy.ORCID 0000-0002-2854-1306
Francesca TurroniLaboratory of Probiogenomics, Department of Chemical Sciences, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
University of Parma · ITNational University of Ireland · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenteric ischemia/reperfusion is a clinical emergency with high morbidity and mortality due to the transient reduction of blood supply to the bowel. In recent years, the critical contribution of gut microbiome to human health and proper gastrointestinal functions has gradually emerged. In the current study, we investigated the protective effects of five days supplementation with Bifidobacterium bifidum PRL2010 in a murine model of gut ischemia/reperfusion. Our findings indicate that animals pretreated with B. bifidum PRL2010 showed lower neutrophil recruitment in the lungs, remarkably reduced bacterial translocation and decreased transcription levels of TNFalpha and IL-10 both in liver and kidneys, at the same time increasing those of IL-12 in kidneys. Inhibiting the adhesion of pathogenic bacteria and boosting host innate immunity responses are among the possible protective mechanisms enacted by the probiotic. These results demonstrate that short-period treatment with B. bifidum PRL2010 is a potential strategy to dampen remote organ injury due to mesenteric ischemia/reperfusion.

Indexed as

AnimalsBifidobacterium bifidumDisease Models, AnimalFecesFemaleImmunity, InnateInterleukin-10IntestinesKidneyLiverLungMalondialdehydeMiceNeutrophilsProbioticsReperfusion InjuryInterleukin-10MalondialdehydeTumor Necrosis Factor-alpha

Identifiers

PMID30161157
PMCPMC6116995
OpenAlexW2889505223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.