Trial reportPloS one2018
Resistance training does not induce uniform adaptations to quadriceps.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Blood flow restriction as an adjunct during mid-stage rehabilitation after ACL reconstruction: a randomized sham-controlled study.BMC musculoskeletal disorders · 2026Trial
- High-intensity interval training and essential amino acid supplementation: Effects on muscle characteristics and whole-body protein turnover.Physiological reports · 2021Trial
- Increased fascicle length but not patellar tendon stiffness after accentuated eccentric-load strength training in already-trained men.European journal of applied physiology · 2020Trial
- Metabolic and perceived effort responses following acute multi-ingredient pre-workout supplementation prior to high-intensity functional training workouts.Frontiers in nutrition · 2026Article
- Effects of knee and hip flexion angle on region-specific and longitudinal compartmental muscle stiffness of the rectus femoris using shear wave elastography in male bodybuilders.European journal of applied physiology · 2025Article
- Article
- Enhanced skeletal muscle contractile function and corticospinal excitability precede strength and architectural adaptations during lower-limb resistance training.European journal of applied physiology · 2023Article
- Does Back Squat Exercise Lead to Regional Hypertrophy among Quadriceps Femoris Muscles?International journal of environmental research and public health · 2022Article
- Reliability and Validity of an Ultrasound-Based Protocol for Measurement of Quadriceps Muscle Thickness in Children.Frontiers in physiology · 2022Article
- Manipulating Resistance Training Variables to Induce Muscle Strength and Hypertrophy: A Brief Narrative Review.International journal of exercise science · 2022Review
- An Examination of Two Resistance Training Frequency Techniques in Morphological and Functional Adaptations of the Patellar Tendon.International journal of exercise science · 2022Article
- Echo intensity as an indicator of skeletal muscle quality: applications, methodology, and future directions.European journal of applied physiology · 2021Review
- Chronic Effects of Heavy Load Activity Performed Before Resistance Training Sessions on the Physical Performance of Youth Soccer Players.International journal of exercise science · 2021Article
- Skeletal Muscle Quality: A Biomarker for Assessing Physical Performance Capabilities in Young Populations.Frontiers in physiology · 2021Review
- Short-term neuromuscular, morphological, and architectural responses to eccentric quasi-isometric muscle actions.European journal of applied physiology · 2021Article
- Methodological considerations for and validation of the ultrasonographic determination of human skeletal muscle hypertrophy and atrophy.Physiological reports · 2021Article
- Exercise induced changes in echo intensity within the muscle: a brief review.Journal of ultrasound · 2020Review
- Does resistance training increase aponeurosis width? The current results and future tasks.European journal of applied physiology · 2020Review
- Tensiomyography Derived Parameters Reflect Skeletal Muscle Architectural Adaptations Following 6-Weeks of Lower Body Resistance Training.Frontiers in physiology · 2019Article
- Effects of High-Intensity Interval Training and Isoinertial Training on Leg Extensors Muscle Function, Structure, and Intermuscular Adipose Tissue in Older Adults.Frontiers in physiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistance training may differentially affect morphological adaptations along the length of uni-articular and bi-articular muscles. The purpose of this study was to compare changes in muscle morphology along the length of the rectus femoris (RF) and vastus lateralis (VL) in response to resistance training. Following a 2-wk preparatory phase, 15 resistance-trained men (24.0 ± 3.0 y, 90.0 ± 13.8 kg, 174.9 ± 20.7 cm) completed pre-training (PRE) assessments of muscle thickness (MT), pennation angle (PA), cross-sectional area (CSA), and echo-intensity in the RF and VL at 30, 50, and 70% of each muscle's length; fascicle length (FL) was estimated from respective measurements of MT and PA within each muscle and region. Participants then began a high intensity, low volume (4 x 3-5 repetitions, 3min rest) lower-body resistance training program, and repeated all PRE-assessments after 8 weeks (2 d ∙ wk-1) of training (POST). Although three-way (muscle [RF, VL] x region [30, 50, 70%] x time [PRE, POST]) repeated measures analysis of variance did not reveal significant interactions for any assessment of morphology, significant simple (muscle x time) effects were observed for CSA (p = 0.002) and FL (p = 0.016). Specifically, average CSA changes favored the VL (2.96 ± 0.69 cm2, p < 0.001) over the RF (0.59 ± 0.20 cm2, p = 0.011), while significant decreases in average FL were noted for the RF (-1.03 ± 0.30 cm, p = 0.004) but not the VL (-0.05 ± 0.36 cm, p = 0.901). No other significant differences were observed. The findings of this study demonstrate the occurrence of non-homogenous adaptations in RF and VL muscle size and architecture following 8 weeks of high-intensity resistance training in resistance-trained men. However, training does not appear to influence region-specific adaptations in either muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.