ArticlePloS one2018
Association between biofilm formation phenotype and clonal lineage in Staphylococcus aureus strains from bone and joint infections.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- In-host adaptation ofMicrobiology spectrum · 2026Article
- Characterization ofBiofilm · 2025Article
- Characterization of antibiotic resistance and biofilm formation in clinical Helicobacter pylori isolates from Ningxia, China.Scientific reports · 2025Article
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- First whole genome sequencing ofOpen veterinary journal · 2024Article
- Genetic determinants of Biofilm formation of Helicobacter pylori using whole-genome sequencing.BMC microbiology · 2023Article
- Sulfur-Polymer Nanoparticles: Preparation and Antibacterial Activity.ACS applied materials & interfaces · 2023Article
- Skin dysbiosis and Cutibacterium acnes biofilm in inflammatory acne lesions of adolescents.Scientific reports · 2022Article
- Anti-Biofilm Activity of Cell Free Supernatants of Selected Lactic Acid Bacteria againstFoods (Basel, Switzerland) · 2022Article
- Role of Extracellular DNA in Dalbavancin Activity against Methicillin-Resistant Staphylococcus aureus (MRSA) Biofilms in Patients with Skin and Soft Tissue Infections.Microbiology spectrum · 2022Article
- Loratadine inhibitsiScience · 2022Article
- Pharmacodynamics of Moxifloxacin, Meropenem, Caspofungin, and Their Combinations againstAntimicrobial agents and chemotherapy · 2022Article
- Virulence Determinants inFrontiers in microbiology · 2022Article
- Comparison of TwoMicroorganisms · 2021Article
- Biofilm Formation in Methicillin-ResistantFrontiers in microbiology · 2021Article
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- Article
- Silence as a way of niche adaptation: mecC-MRSA with variations in the accessory gene regulator (agr) functionality express kaleidoscopic phenotypes.Scientific reports · 2020Article
- Antibiotic Tolerance ofAntibiotics (Basel, Switzerland) · 2020Review
- Genomic characterization and outcome of prosthetic joint infections caused by Staphylococcus aureus.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biofilm formation is a critical virulence factor responsible for treatment failure and chronicity in orthopaedic device-related infections (ODIs) caused by Staphylococcus aureus. Clonal lineages differ in terms of their biofilm forming capacities. The aim of this study was to investigate the correlation between the clonal complex (CC) affiliation and biofilm phenotype of 30 clinical S. aureus isolates responsible of ODI based on i) early biofilm formation using BioFilm Ring Test® and mature biofilm formation using crystal violet assays, ii) biofilm composition using DNase and proteinase K activity, and iii) prevention of biofilm formation by cloxacillin, teicoplanin and vancomycin using Antibiofilmogram® (biofilm minimal inhibitory concentration-bMIC). In terms of early biofilm formation, the CC30 strains were significantly slower than the CC5, CC15 and CC45 strains. CC45 strains produced significantly more mature biofilm than other group of strains did. The formation of biofilms was highly dependent on the presence of extracellular DNA in the CC5, CC15 and CC30 strains whereas it was mostly dependent on the presence of proteins in CC45. Finally, the CC30 group highlighted higher proportion of susceptible (bMIC < breakpoints of EUCAST guidelines) for cloxacillin, teicoplanin and vancomycin compared to the other CCs. These results demonstrate that the biofilm phenotype of clinical S. aureus isolates from ODIs is strongly related to their respective CC affiliation.
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