ArticleJournal of addiction medicine
Alcohol and Drug Overdose and the Influence of Pain Conditions in an Addiction Treatment Sample.
Article in Journal of addiction medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Patient navigation for pregnant individuals with opioid use disorder: Results of a randomized multi-site pilot trial.Addiction (Abingdon, England) · 2024Trial
- Relationships among childhood trauma, central sensitization, and opioid-related risks in a community sample of adults with chronic pain on opioids.Pain medicine (Malden, Mass.) · 2026Article
- Association between gabapentinoid treatment, concurrent use with opioid or benzodiazepine and the risk of drug poisoning: A self-controlled case series study.PLoS medicine · 2026Article
- VA Primary Care Patients with Chronic Pain: A Comparison of Healthcare Utilization and Patient Characteristics Across Alcohol Risk Categories.Journal of clinical psychology in medical settings · 2025Article
- Recent advances in the treatment of chronic pain and substance use disorders.Current opinion in psychology · 2025Review
- Pain prospectively predicts alcohol use disorder among people living with HIV: A commentary on Palfai et al. (2024).Alcohol, clinical & experimental research · 2025Article
- Cluster analysis to identify patient profiles and substance use patterns among pregnant persons with opioid use disorder.Addictive behaviors reports · 2023Article
- Prevalence and correlates of using opioids alone among individuals in a residential treatment program in Michigan: implications for overdose mortality prevention.Harm reduction journal · 2022Article
- Pain Severity and Interference and Substance Use Among Community Pharmacy Patients Prescribed Opioids: A Secondary Analysis of the PHARMSCREEN Study.The journal of pain · 2022Article
- Risky alcohol use among patients dispensed opioid medications: A clinical community pharmacy study.Drug and alcohol dependence · 2022Article
- Article
- Associations between elevated depressive symptoms and substance use, prescription opioid misuse, overdose history, pain, and general health among community pharmacy patients prescribed opioids.Substance abuse · 2022Article
- Association between recent overdose and chronic pain among individuals in treatment for opioid use disorder.PloS one · 2022Article
- Validation and threshold identification of a prescription drug monitoring program clinical opioid risk metric with the WHO alcohol, smoking, and substance involvement screening test.Drug and alcohol dependence · 2021Article
- Concomitant Cannabis Misuse and Associations with Depression, Pain and Substance Misuse among Patients Prescribed Opioids.Pharmacy (Basel, Switzerland) · 2021Article
- Opportunities to boost naloxone awareness among people who misuse opioid analgesics who have not used illegal opioids.Substance abuse · 2021Article
- A comprehensive multivariate model of biopsychosocial factors associated with opioid misuse and use disorder in a 2017-2018 United States national survey.BMC public health · 2020Article
- Pain interference and catastrophizing are not associated with polysubstance use among treatment-seeking patients with substance use disorders and chronic pain.The American journal of drug and alcohol abuse · 2020Article
- Prevalence of and Risk Factors Associated With Nonfatal Overdose Among Veterans Who Have Experienced Homelessness.JAMA network open · 2020Article
- Justice involvement patterns, overdose experiences, and naloxone knowledge among men and women in criminal justice diversion addiction treatment.Harm reduction journal · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeOverdose from alcohol and/or drugs kills tens of thousands of Americans annually, with a large number of deaths attributed to opioid pain medications. Addiction treatment patients are known to be at high risk for overdose; however, the relationship between pain and overdose history within this group is understudied, especially in relation to alcohol overdoses. In the present study, we evaluated whether nonfatal overdose history was more likely among addiction treatment patients with pain, and examined the characteristics of overdoses among those with and without pain.
methodsWe analyzed cross-sectional data from 739 patients at a large residential addiction treatment center (median age 37, 25.7% female). We used 2-stepped binary regression models to evaluate whether demographics, pain type (chronic, acute, or both), depression symptoms, and opioid misuse were associated with lifetime history of nonfatal (1) alcohol and (2) drug overdose (lifetime yes/no), and conducted follow-up analyses examining overdose characteristics.
resultsIn adjusted analyses, history of chronic pain (odds ratio [OR] 2.60, 95% confidence interval [CI] 1.59, 4.27) and illicit drug use (OR 1.99, 95% CI 1.07, 3.68) were associated with an increased likelihood of nonfatal alcohol overdose. Opioid misuse (OR 3.11, 95% CI 2.51, 3.86), depression symptoms (OR 1.33, 95% CI 1.14, 1.55), and younger age (OR 0.96, 95% CI 0.94, 0.97) were associated with increased likelihood of drug overdose. Those with pain reported a higher number of lifetime alcohol overdoses and were more likely to combine numerous drugs with alcohol before overdose.
conclusionsPain conditions may play an under-recognized role in the overdose epidemic, particularly alcohol-related overdose. Addiction treatment and overdose prevention interventions should incorporate appropriate assessment and treatment of pain including education about the risks of polysubstance use, particularly combining alcohol with sedatives and prescription pain relievers.
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