ArticleJournal of applied physiology (Bethesda, Md. : 1985)2018
Daytime loop gain is elevated in obstructive sleep apnea but not reduced by CPAP treatment.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Effect of acetazolamide on susceptibility to central sleep apnea in chronic spinal cord injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- TMD and Bruxism as Expressions of Central Regulatory State: The Functional Occlusion Regulated Model (FORM).Journal of clinical medicine · 2026Review
- Pediatric OSA-Spectrum of the Disease and Opportunities for Personalized Interventions.Journal of personalized medicine · 2026Review
- Article
- Loop Gain in Obstructive Sleep Apnea: From Physiological Endotype to Clinical Translation.Nature and science of sleep · 2026Review
- The Link Between Sleep-Related Breathing Disorders and Idiopathic Pulmonary Fibrosis: Pathophysiological Mechanisms and Treatment Options-A Review.Journal of clinical medicine · 2025Review
- Morphological Prediction of Continuous Positive Airway Pressure-associated Acute Respiratory Instability.Annals of the American Thoracic Society · 2025Article
- Role of Nasal Surgery in Adult Obstructive Sleep Apnea: A Systematic Review.Sleep science (Sao Paulo, Brazil) · 2024Review
- Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome.Signal transduction and targeted therapy · 2023Review
- A comprehensive review of respiratory, autonomic and cardiovascular responses to intermittent hypoxia in humans.Experimental neurology · 2021Review
- Breathing Re-Education and Phenotypes of Sleep Apnea: A Review.Journal of clinical medicine · 2021Review
- Model for Identifying High Carotid Body Chemosensitivity in Patients with Obstructive Sleep Apnea.Nature and science of sleep · 2021Article
- Breathing retraining in sleep apnoea: a review of approaches and potential mechanisms.Sleep & breathing = Schlaf & Atmung · 2020Review
- The Role of Animal Models in Developing Pharmacotherapy for Obstructive Sleep Apnea.Journal of clinical medicine · 2019Review
- More Than the Sum of the Respiratory Events: Personalized Medicine Approaches for Obstructive Sleep Apnea.American journal of respiratory and critical care medicine · 2019Review
- Contribution of the Lung to the Genesis of Cheyne-Stokes Respiration in Heart Failure: Plant Gain Beyond Chemoreflex Gain and Circulation Time.Journal of the American Heart Association · 2019Article
- Central sleep apnea: misunderstood and mistreated!F1000Research · 2019Review
- Inherent vs. Induced Loop Gain Abnormalities in Obstructive Sleep Apnea.Frontiers in neurology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Reduced ventilatory control stability (elevated loop gain) is a key nonanatomical, pathological trait contributing to obstructive sleep apnea (OSA), yet the mechanisms responsible remain unclear. We sought to identify the key factors contributing to elevated loop gain in OSA (controller vs. plant contributions) and to examine whether abnormalities in these factors persist after OSA treatment. In 15 males (8 OSA, 7 height, weight- and age -matched controls), we measured loop gain, controller gain, and plant gain using a pseudorandom binary CO
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.