Evidence map›Paper›PMID 30161006›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2018

Spinal protein phosphatase 1 constrains respiratory plasticity after sustained hypoxia.

Adrianne G Huxtable, Timothy J Peterson, Jonathan N Ouellette, Jyoti J Watters, Gordon S Mitchell

Open access · bronzeAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Passive siRNA transfection method for gene knockdown in air-liquid interface airway epithelial cell cultures.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  6. Review
  7. Cervical spinal 5-HTJournal of applied physiology (Bethesda, Md. : 1985) · 2019
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Adrianne G HuxtableDepartment of Comparative Biosciences, University of Wisconsin , Madison, Wisconsin.
Timothy J PetersonDepartment of Comparative Biosciences, University of Wisconsin , Madison, Wisconsin.
Jonathan N OuelletteDepartment of Comparative Biosciences, University of Wisconsin , Madison, Wisconsin.
Jyoti J WattersDepartment of Comparative Biosciences, University of Wisconsin , Madison, Wisconsin.
Gordon S MitchellDepartment of Comparative Biosciences, University of Wisconsin , Madison, Wisconsin.
University of Wisconsin–Madison · USUniversity of Oregon · US

Funding

Intermittent Hypoxia-Induced Inflammation Modulates Respiratory PlasticityR01HL111598 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S., WATTERS, JYOTI J · 2012 to 2016
$2.9M
NHLBI NIH HHS R01 HL111598
6 · The paper itself

Abstract

Plasticity is an important aspect of the neural control of breathing. One well-studied form of respiratory plasticity is phrenic long-term facilitation (pLTF) induced by acute intermittent but not sustained hypoxia. Okadaic acid-sensitive protein phosphatases (PPs) differentially regulate phrenic nerve activity with intermittent vs. sustained hypoxia, at least partially accounting for pLTF pattern sensitivity. However, okadaic acid inhibits multiple serine/threonine phosphatases, and the relevant phosphatase (PP1, PP2A, PP5) for pLTF pattern sensitivity has not been identified. Here, we demonstrate that sustained hypoxia (25 min, 9-10.5% O

Indexed as

Respiratory MechanicsAnimalsHypoxiaMaleNeuronal PlasticityPC12 CellsPhrenic NerveProtein Phosphatase 1Protein Phosphatase 2RatsRats, Sprague-DawleyRNA, Small InterferingProtein Phosphatase 1Protein Phosphatase 2RNA, Small Interferingphrenic motoneuronsplasticityprotein phosphataserespiratory motor plasticitysiRNA

Identifiers

PMID30161006
PMCPMC6295481
OpenAlexW2889192397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.