ArticleEuropean journal of immunology2018
The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis.
Article in European journal of immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Enhanced MIF/CD74 axis activity shapes B cell functioning following traumatic spinal cord injury.Journal of neuroinflammation · 2026Article
- Macrophage migration inhibitory factor: Exploring physiological roles and comparing health benefits against oncogenic and autoimmune risks (Review).International journal of molecular medicine · 2025Review
- Glial Activation Enhances Spinal TRPV1 Receptor Sensitivity in a Paclitaxel Model of Neuropathic Pain.Physiological research · 2025Article
- Granzyme B+ B cells detected by single-cell sequencing are associated with prognosis in patients with intrahepatic cholangiocarcinoma following liver transplantation.Cancer immunology, immunotherapy : CII · 2024Article
- MIF contribution to progressive brain diseases.Journal of neuroinflammation · 2024Review
- Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype.Mucosal immunology · 2023Article
- Altered Circulating Immune Cell Distribution in Traumatic Spinal Cord Injury Patients in Relation to Clinical Parameters.Frontiers in immunology · 2022Article
- Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Pregnancy-induced effects on memory B-cell development in multiple sclerosis.Scientific reports · 2021Article
- Molecular Examination of Differentially Expressed Genes in the Brains of Experimental Autoimmune Encephalomyelitis Mice Post Herceptin Treatment.Journal of inflammation research · 2021Article
- [Ocrelizumab for treatment of multiple sclerosis].Der Nervenarzt · 2020Review
- D-dopachrome tautomerase from Japanese sea bass (Zoological research · 2020Article
- MIF-Dependent Control of Tumor Immunity.Frontiers in immunology · 2020Review
- Upregulated Expression of Macrophage Migration Inhibitory Factor, Its Analogue D-Dopachrome Tautomerase, and the CD44 Receptor in Peripheral CD4 T Cells from Clinically Isolated Syndrome Patients with Rapid Conversion to Clinical Defined Multiple Sclerosis.Medicina (Kaunas, Lithuania) · 2019Article
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11 authors at 2 institutions in 1 country.
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Abstract
In MS, B cells survive peripheral tolerance checkpoints to mediate local inflammation, but the underlying molecular mechanisms are relatively underexplored. In mice, the MIF pathway controls B-cell development and the induction of EAE. Here, we found that MIF and MIF receptor CD74 are downregulated, while MIF receptor CXCR4 is upregulated in B cells from early onset MS patients. B cells were identified as the main immune subset in blood expressing MIF. Blocking of MIF and CD74 signaling in B cells triggered CXCR4 expression, and vice versa, with separate effects on their proinflammatory activity, proliferation, and sensitivity to Fas-mediated apoptosis. This study reveals a new reciprocal negative regulation loop between CD74 and CXCR4 in human B cells. The disturbance of this loop during MS onset provides further insights into how pathogenic B cells survive peripheral tolerance checkpoints to mediate disease activity in MS.
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