ArticleBrain and behavior2018
Psychiatric profile of motor subtypes of de novo drug-naïve Parkinson's disease patients.
Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A Canonical Neural Map and Its Deviations Shape Parkinson's Disease Phenotypes.Research square · 2026Article
- Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson's Disease.Journal of personalized medicine · 2021Article
- Functional and Cognitive Improvement After an Intensive Inpatient Multidisciplinary Rehabilitation Program in Mild to Severe Parkinson's Disease: A Retrospective and Observational Study.Frontiers in neurology · 2021Article
- α-Synuclein in blood cells differentiates Parkinson's disease from healthy controls.Annals of clinical and translational neurology · 2019Article
- Psychiatric profile of motor subtypes of de novo drug-naïve Parkinson's disease patients.Brain and behavior · 2018Article
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Authors and funding
10 authors.
Funding
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Abstract
backgroundParkinson's disease (PD) is a heterogeneous neurodegenerative disorder. It is well established that different motor subtypes of PD evolve with different clinical courses and prognoses. The complete psychiatric profile underlying these different phenotypes since the very early stage of the disease is debated. AIMS OF THE STUDY: We aimed at investigating the psychiatric profile of the three motor subtypes of PD (akinetic-rigid, tremor-dominant, and mixed) in de novo drug-naïve patients with PD.
methodsSixty-eight patients with PD, divided into 39 akinetic-rigid (AR), seven mixed (MIX), and 22 tremor-dominant (TD) patients underwent a complete assessment of psychiatric, cognitive, and motor symptoms.
resultsNo significant differences were found among groups.
conclusionsOur results suggest that a differentiation of the psychiatric symptoms associated with specific motor subtypes of PD is not detectable in de novo drug-naïve patients. Previous evidence that emerges later along the disease progression may be a consequence of the dopaminergic and nondopaminergic damage increase.
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