Evidence map›Paper›PMID 30160335›Full record

Trial reportNeuromodulation : journal of the International Neuromodulation Society2019

Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: Neuromodulation of the Femoral Nerve for Postoperative Analgesia Following Ambulatory Anterior Cruciate Ligament Reconstruction: A Proof of Concept Study.

Brian M Ilfeld, Engy T Said, John J Finneran, Jacklynn F Sztain, Wendy B Abramson, Rodney A Gabriel, Bahareh Khatibi, Matthew W Swisher, Pia Jaeger, Dana C Covey and 1 more

5 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuromodulation : journal of the International Neuromodulation Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02898103 nacompletednot on this map

Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Analgesia: A Feasibility/Proof-of-Concept Study

TypeinterventionalSponsorUniversity of California, San DiegoRan2017 to 2018Enrolled7ConditionsPostoperative PainArmsPercutaneous peripheral nerve stimulation, Sham stimulation
NCT03738748 nacompletednot on this mapstarted 2024, after this paper: background citation

Effectiveness of the Ecoguided Percutaneous Neuromodulation of the Multipurpose Musculature of L-3 in Non-specific Chronic Lumbar Pain.

TypeinterventionalSponsorUniversidad de AlmeriaRan2024 to 2025Enrolled70ConditionsLow Back PainArmsUltrasound- guided Percutaneous Neuromulation, TENS Therapy
NCT04670042 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Feasibility and Effectiveness of Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) Following Total Knee Arthroplasty.

TypeinterventionalSponsorStanford UniversityRan2021 to 2024Enrolled0ConditionsInjury, Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain, Total Knee ArthroplastyArmsSPRINT® Peripheral Nerve Stimulation (PNS) System (510k Cleared)
NCT05606250 nacompletednot on this mapstarted 2022, after this paper: background citation

Effectiveness of the Ultrasound-guided Percutaneous Neuromodulation Technique in Post-surgical Anterior Cruciate Ligament Patients

TypeinterventionalSponsorUniversidad Europea de MadridRan2022 to 2024Enrolled70ConditionsACL InjuryArmsUltrasound-Guided Percutaneous Neuromodulation
NCT05826301 nacompletednot on this mapstarted 2020, after this paper: background citation

Percutaneous Neuromodulation in Tibial Nerve vs. Electrolysis in Plantar Fasciitis Subjects

TypeinterventionalSponsorUniversidad Europea de MadridRan2020 to 2023Enrolled67ConditionsPlantar FascitisArmsPercutaneous neuromodulation in tibial nerve, Percutaneous electrolysis
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

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  4. Updates in ultrasound-guided musculoskeletal interventions.The British journal of radiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Brian M IlfeldDepartment of Anesthesiology, University of California, San Diego, San Diego, CA, USA.
Engy T SaidDepartment of Anesthesiology, University of California, San Diego, San Diego, CA, USA.
John J FinneranDepartment of Anesthesiology, University of California, San Diego, San Diego, CA, USA.
Jacklynn F SztainDepartment of Anesthesiology, University of California, San Diego, San Diego, CA, USA.
Wendy B AbramsonDepartment of Anesthesiology, University of California, San Diego, San Diego, CA, USA.
Rodney A GabrielDepartment of Anesthesiology, University of California, San Diego, San Diego, CA, USA.
Bahareh KhatibiDepartment of Anesthesiology, University of California, San Diego, San Diego, CA, USA.
Matthew W SwisherDepartment of Anesthesiology, University of California, San Diego, San Diego, CA, USA.
Pia JaegerOutcomes Research consortium, Cleveland, OH, USA.
Dana C CoveyDepartment of Orthopedic Surgery, University of California, San Diego, San Diego, CA, USA.
Catherine M RobertsonDepartment of Orthopedic Surgery, University of California, San Diego, San Diego, CA, USA.
University of California, San Diego · USOutcomes Research Consortium · USRigshospitalet · DK

Funding

SPR TherapeuticsUniversity California Academic Senate
6 · The paper itself

Abstract

objectivesThe purpose of this prospective proof of concept study was to investigate the feasibility of using percutaneous peripheral nerve stimulation of the femoral nerve to treat pain in the immediate postoperative period following ambulatory anterior cruciate ligament reconstruction with a patellar autograft. MATERIALS AND

methodsPreoperatively, an electrical lead (SPRINT, SPR Therapeutics, Inc., Cleveland, OH, USA) was percutaneously implanted with ultrasound guidance anterior to the femoral nerve caudad to the inguinal crease. Within the recovery room, subjects received 5 min of either stimulation or sham in a randomized, double-masked fashion followed by a 5-min crossover period, and then continuous active stimulation until lead removal postoperative Day 14-28. Statistics were not applied to the data due to the small sample size of this feasibility study.

resultsDuring the initial 5-min treatment period, subjects randomized to stimulation (n = 5) experienced a slight downward trajectory (decrease of 7%) in their pain over the 5 min of treatment, while those receiving sham (n = 5) reported a slight upward trajectory (increase of 4%) until their subsequent 5-min stimulation crossover, during which time they also experienced a slight downward trajectory (decrease of 11% from baseline). A majority of subjects (80%) used a continuous adductor canal nerve block for rescue analgesia (in addition to stimulation) during postoperative Days 1-3, after which the median resting and dynamic pain scores remained equal or less than 1.5 on the numeric rating scale, respectively, and the median daily opioid consumption was less than 1.0 tablet.

conclusionsThis proof of concept study demonstrates that percutaneous femoral nerve stimulation is feasible for ambulatory knee surgery; and suggests that this modality may be effective in providing analgesia and decreasing opioid requirements following anterior cruciate ligament reconstruction. clinicaltrials.gov: NCT02898103.

Indexed as

Proof of Concept StudyAdultAmbulatory Surgical ProceduresAnalgesiaAnterior Cruciate Ligament ReconstructionCross-Over StudiesDouble-Blind MethodElectrodes, ImplantedFemaleFemoral NerveHumansMalePain MeasurementPostoperative PainProspective StudiesTranscutaneous Electric Nerve StimulationAmbulatory surgeryneuromodulationoutpatient surgerypercutaneous peripheral nerve stimulationpostoperative analgesia

Identifiers

PMID30160335
PMCPMC6767389
OpenAlexW2888808241

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.