Evidence map›Paper›PMID 30160305›Full record

ArticleCommunity dentistry and oral epidemiology2018

Periodontitis and multiple markers of cardiometabolic risk in the fourth decade: A cohort study.

Dara M Shearer, W Murray Thomson, Claire M Cameron, Sandhya Ramrakha, Graham Wilson, Tien Yin Wong, Michael J A Williams, Rachael McLean, Reremoana Theodore, Richie Poulton

Abstract read
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In one paragraph

Article in Community dentistry and oral epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Dara M ShearerDepartment of Oral Sciences, Faculty of Dentistry, Dunedin, New Zealand.ORCID 0000-0002-5363-4889
W Murray ThomsonDepartment of Oral Sciences, Faculty of Dentistry, Dunedin, New Zealand.ORCID 0000-0003-0588-6843
Claire M CameronDepartment of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Sandhya RamrakhaDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
Graham WilsonDepartment of Ophthalmology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Michael J A WilliamsDepartment of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Rachael McLeanDepartment of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Reremoana TheodoreDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
Richie PoultonDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
University of Otago · NZDunedin Public Hospital · NZNational University of Singapore · SG

Funding

Is mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5M
SELF-REPORT DELINQUENCY: A LONGITUDINAL STUDYR01MH045070 · NIMH · UNIVERSITY OF WISCONSIN MADISON · PI MOFFITT, TERRIE EDITH · 1989 to 2006
$2.5M
Personality and Health from Childhood to AdulthoodR01MH049414 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI CASPI, AVSHALOM · 1997 to 2006
$1.8M
Oral health disparities in the first 4 decades of lifeR01DE015260 · NIDCR · UNIVERSITY OF OTAGO · PI THOMSON, WILLIAM MURRAY · 2004 to 2007
$591k
Generating new knowledge to support reversibility interventionsR01AG048895 · NIA · DUKE UNIVERSITY · PI MOFFITT, TERRIE E · 2014 to 2015
$311k
Medical Research Council G0100527Medical Research Council G0601483Medical Research Council MR/P005918/1NIA NIH HHS R01 AG032282NIA NIH HHS R01 AG048895NIDCR NIH HHS R01 DE015260NIMH NIH HHS R01 MH045070NIMH NIH HHS R01 MH049414UK Medical Research Council MR/K00381XUK Medical Research Council MR/P005918/1
6 · The paper itself

Abstract

objectivesTo examine associations between periodontitis at ages 32 and 38 and a range of early cardiometabolic risk biomarkers at age 38.

methodsPeriodontal probing depth and bleeding on probing data collected during the age-32 and age-38 assessments in the Dunedin Multidisciplinary Health and Development Study were used to quantify periodontal inflammatory load. Retinal microvascular abnormalities, endothelial dysfunction, and metabolic syndrome data were collected during the age-38 assessment. Regression models were used to examine associations between these cardiometabolic risk markers and (1) the inflammatory load at age 38 and (2) the change in inflammatory load between ages 32 and 38.

resultsPeriodontal inflammatory load was recorded for 890 Study members at age 32, 891 at age 38, and 856 at both ages. Retinal vessel data were available for 922, endothelial dysfunction data for 909 and metabolic syndrome data for 905 at age 38. Neither the inflammatory load of periodontitis at 38 nor the changes in inflammatory load 32-38 were found to be associated with any of the three cardiometabolic risk markers.

conclusionsPeriodontitis was not associated with markers of cardiometabolic risk at this relatively early stage in the life course. It is possible that any influence of periodontitis on cardiometabolic health develops later in life, or periodontitis is not involved in the putative causal chain comprising systemic inflammation, cardiometabolic risk markers, and subsequent cardiovascular risk.

Indexed as

AdultBiomarkersCardiovascular DiseasesCholesterol, HDLChronic PeriodontitisCohort StudiesEndothelium, VascularFemaleGlycated HemoglobinHumansMaleMetabolic SyndromeNew ZealandPeriodontal IndexRetinal VesselsRisk FactorsBiomarkersCholesterol, HDLGlycated Hemoglobinhemoglobin A1c protein, humanTriglyceridescardiometabolicendothelial dysfunctionmetabolic syndromemicrocirculationperiodontitisperipheral arterial tonometryretinal vascular calibre

Identifiers

PMID30160305
PMCPMC6237628
OpenAlexW2889382923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.