ArticleDevelopmental science2019
Laterality of the frontal aslant tract (FAT) explains externalizing behaviors through its association with executive function.
Article in Developmental science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The Frontal Aslant Tract: A Systematic Review for Neurosurgical Applications.Frontiers in neurology · 2021Pooled it
- Same, Same but Different? A Multi-Method Review of the Processes Underlying Executive Control.Neuropsychology review · 2024Review
- Probabilistic coverage of the frontal aslant tract in young adults: Insights into individual variability, lateralization, and language functions.Human brain mapping · 2024Article
- Connectivity by the Frontal Aslant Tract (FAT) Explains Local Functional Specialization of the Superior and Inferior Frontal Gyri in Humans When Choosing Predictive over Reactive Strategies: A Tractography-Guided TMS Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Polygenic risk scores and brain structures both contribute to externalizing behavior in childhood - A study in the Adolescent Brain and Cognitive Development (ABCD) cohort.Neuroscience applied · 2023Article
- Structural and diffusion-weighted brain imaging predictors of attention-deficit/hyperactivity disorder and its symptomology in very young (4- to 7-year-old) children.The European journal of neuroscience · 2022Article
- White matter tract strength correlates with therapy outcome in persistent developmental stuttering.Human brain mapping · 2022Article
- A nationwide cohort study on the risk of ADHD in children with amblyopia mediated by fine motor skill impairment in East Asia.Scientific reports · 2022Article
- Multivariate Genetic Structure of Externalizing Behavior and Structural Brain Development in a Longitudinal Adolescent Twin Sample.International journal of molecular sciences · 2022Article
- Frontal aslant tract in the non-dominant hemisphere: A systematic review of anatomy, functions, and surgical applications.Frontiers in neuroanatomy · 2022Review
- Frontal aslant tract: Anatomy and tractography description in the Mexican population.Surgical neurology international · 2022Article
- Bilingualism, Executive Function, and the Brain: Implications for Autism.Neurobiology of language (Cambridge, Mass.) · 2021Review
- Registration-free analysis of diffusion MRI tractography data across subjects through the human lifespan.NeuroImage · 2020Article
- A unified model of post-stroke language deficits including discourse production and their neural correlates.Brain : a journal of neurology · 2020Article
- Distinct Components in the Right Extended Frontal Aslant Tract Mediate Language and Working Memory Performance: A Tractography-Informed VBM Study.Frontiers in neuroanatomy · 2020Article
- Cortical morphometry and structural connectivity relate to executive function and estradiol level in healthy adolescents.Brain and behavior · 2019Article
- The frontal aslant tract (FAT) and its role in speech, language and executive function.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Review
- Role of the frontal aslant tract in language preservation and recovery after surgery: a multicenter analysis of patients with left frontal glioma.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated the development of a recently identified white matter pathway, the frontal aslant tract (FAT) and its association with executive function and externalizing behaviors in a sample of 129 neurotypical male and female human children ranging in age from 7 months to 19 years. We found that the FAT could be tracked in 92% of those children, and that the pathway showed age-related differences into adulthood. The change in white matter microstructure was very rapid until about 6 years, and then plateaued, only to show age-related increases again after the age of 11 years. In a subset of those children (5-18 years; n = 70), left laterality of the microstructural properties of the FAT was associated with greater attention problems as measured by the Child Behavior Checklist (CBCL). However, this relationship was fully mediated by higher executive dysfunction as measured by the Behavior Rating Inventory of Executive Function (BRIEF). This relationship was specific to the FAT-we found no relationship between laterality of a control pathway, or of the white matter of the brain in general, and attention and executive function. These findings suggest that the degree to which the developing brain favors a right lateralized structural dominance of the FAT is directly associated with executive function and attention. This novel finding provides a new potential structural biomarker to assess attention deficit hyperactivity disorder (ADHD) and associated executive dysfunction during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.