Evidence map›Paper›PMID 30159779›Full record

Trial reportCancer immunology, immunotherapy : CII2018

Molecular subgroups and B7-H4 expression levels predict responses to dendritic cell vaccines in glioblastoma: an exploratory randomized phase II clinical trial.

Yu Yao, Feifei Luo, Chao Tang, Dikang Chen, Zhiyong Qin, Wei Hua, Ming Xu, Ping Zhong, Shuangquan Yu, Di Chen and 10 more

Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer immunology, immunotherapy : CII, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01567202 (A Triple-blind Randomized Clinical Study of Vaccination With Dendritic Cells Loaded With Glioma Stem-like Cells Associated Antigens Against Brain Glioblastoma Multiform), which is not on this map. Cited by 70 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 13 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01567202 phase2unknown statusnot on this map

A Triple-blind Randomized Clinical Study of Vaccination With Dendritic Cells Loaded With Glioma Stem-like Cells Associated Antigens Against Brain Glioblastoma Multiform

TypeinterventionalSponsorHuashan HospitalRan2012 to 2021Enrolled100ConditionsGlioma, Glioblastoma Multiforme, NeoplasmsArmsSurgery, Chemotherapy, Radiotherapy, DC vaccination, blank placebo
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 13 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Autologous tumor lysate-loaded dendritic cell vaccination in glioblastoma patients: a systematic review of literature.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. A systematic review of immunotherapy in high-grade glioma: learning from the past to shape future perspectives.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Article
  15. Review
  16. Article
  17. Current Status and Evolution of Immunotherapy in Glioma Management.International journal of medical sciences · 2026
    Review
  18. Article
  19. Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Yu YaoDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Feifei LuoBiotherapy Research Center of Fudan University and Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Chao TangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Dikang ChenDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhiyong QinDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Wei HuaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Ming XuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Ping ZhongDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Shuangquan YuDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Di ChenDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xiaojie DingDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yi ZhangDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xiujuan ZhengDepartment of Immunology and Biotherapy Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Jiao YangDepartment of Immunology and Biotherapy Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Jiawen QianDepartment of Immunology and Biotherapy Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Yuting DengDepartment of Immunology and Biotherapy Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Dave S B HoonDepartment of Translational Molecular Medicine, John Wayne Cancer Institute (JWCI), Pacific Neuroscience Institute, Saint John's Health Center, Providence Health Systems, Santa Monica, CA, 90404, USA.
Jian HuDepartment of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Yiwei ChuDepartment of Immunology and Biotherapy Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. ywchu@shmu.edu.cn.
Liangfu ZhouDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. lfzhouc@126.com.
Fudan University · CNHuashan Hospital · CNSaint John's Health Center · USThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cell (DC)-based vaccination is a promising approach for active-specific immunotherapy, but is currently of limited efficacy. The safety and effectiveness of a DC vaccine (DCV) loaded with glioblastoma stem cell-like (GSC) antigens was assessed in glioblastoma multiforme (GBM) patients. In this double-blind, placebo-controlled phase II clinical trial, 43 GBM patients were randomized after surgery at a 1:1 ratio to receive either DCV (n = 22) or normal saline placebo (n = 21). Overall survival (OS) and progression-free survival (PFS) were analysed. Participants were stratified into different molecular subgroups based on the mutation (MT) status of isocitrate dehydrogenase (IDH1/2) and telomerase reverse transcriptase (TERT). Plasma cytokine levels, tumor-infiltrating lymphocyte numbers and immune co-inhibitory molecules PD-L1 and B7-H4 were also assessed. Multivariate Cox regression analysis revealed that DCV treatment significantly prolonged OS (p = 0.02) after adjusting for IDH1 and TERT promoter MT and B7-H4 expression, primary vs recurrent GBM. Among IDH1

Indexed as

MutationAdolescentAdultAgedBiomarkers, TumorBrain NeoplasmsCancer VaccinesCombined Modality TherapyDendritic CellsDouble-Blind MethodFemaleFollow-Up StudiesGlioblastomaHumansIsocitrate DehydrogenaseMaleBiomarkers, TumorCancer VaccinesIDH1 protein, humanIDH2 protein, humanIsocitrate DehydrogenaseTelomeraseTERT protein, humanV-Set Domain-Containing T-Cell Activation Inhibitor 1VTCN1 protein, humanActive-specific immunotherapyB7-H4Dendritic cell vaccineGlioblastoma multiformeIDHTERT

Identifiers

PMID30159779
PMCPMC11028057
OpenAlexW2888273332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.