Evidence map›Paper›PMID 30159750›Full record

ReviewMikrochimica acta2018

Advances in nanomaterial based optical biosensing and bioimaging of apoptosis via caspase-3 activity: a review.

Balal Khalilzadeh, Nasrin Shadjou, Gulsah Saydan Kanberoglu, Hadi Afsharan, Miguel de la Guardia, Hojjatollah Nozad Charoudeh, Alireza Ostadrahimi, Mohammad-Reza Rashidi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mikrochimica acta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Journal of traditional and complementary medicine · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Inhibition of STAT3Cell death discovery · 2022
    Article
  11. Cannabidiol promotes apoptosis of osteosarcoma cellsAmerican journal of translational research · 2022
    Article
  12. Review
  13. Shikonin attenuates HExperimental and therapeutic medicine · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Balal KhalilzadehStem Cell Research Center (SCRC), Tabriz University of Medical Sciences, Tabriz, 51664-14766, Iran. khalilzadehb@tbzmed.ac.ir.ORCID 0000-0003-2262-6453
Nasrin ShadjouDepartment of Nanochemistry and Nanotechnology Center, Urmia University, Urmia, 57154, Iran. Nasrin.Shadjou@gmail.com.
Gulsah Saydan KanberogluDepartment of Chemistry, Faculty of Sciences, Van Yuzuncu Yil University, 65080, Van, Turkey.
Hadi AfsharanFaculty of Physics, Iran University of Science and Technology, Tehran, 16846-13114, Iran.
Miguel de la GuardiaDepartment of Analytical Chemistry, University of Valencia, Dr. Moliner 50, 46100, Burjassot, Valencia, Spain.
Hojjatollah Nozad CharoudehStem Cell Research Center (SCRC), Tabriz University of Medical Sciences, Tabriz, 51664-14766, Iran.
Alireza OstadrahimiNutrition Research Center, Tabriz University of Medical Sciences, Tabriz, 51666-14711, Iran.
Mohammad-Reza RashidiResearch Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Sciences, Tabriz, 51664-14766, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caspase-3 plays a vital role in intrinsic and extrinsic pathways of programed cell death and in cell proliferation. Its detection is an important tool for early detection of some cancers and apoptosis-related diseases, and for monitoring the efficacy of pharmaceuticals and of chemo- and radiotherapy of cancers. This review (with 72 references) summarizes nanomaterial based methods for signal amplification in optical methods for the determination of caspase-3 activity. Following an introduction into the field, a first large section covers optical assays, with subsections on luminescent and chemiluminescence, fluorometric (including FRET based), and colorimetric assays. Further section summarize methods for bioimaging of caspase-3. A concluding section covers current challenges and future perspectives. Graphical Abstract ᅟ.

Indexed as

ApoptosisNanostructuresBiosensing TechniquesCaspase 3HumansMolecular ImagingNanotechnologyCaspase 3BioimagingBiomedical analysisCancerCaspase-3NanotechnologyOptical biosensing

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.