ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2018
Prevalence of hepatitis E virus viremia and antibodies among healthy blood donors in India.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- A systematic review and meta-analysis of predictors of human hepatitis E virus exposure in non-endemic countries.Zoonoses and public health · 2020Pooled it
- Hepatitis E virus (HEV) as an emerging challenge in Poland: a narrative review of epidemiological and clinical data.Archives of medical science : AMS · 2026Article
- The Use of Residual Blood Specimens in Seroprevalence Studies for Vaccine-Preventable Diseases: A Scoping Review.Vaccines · 2025Review
- Assessment of Hepatitis E virus transmission risks: a comprehensive review of cases among blood transfusion recipients and blood donors.Infection ecology & epidemiology · 2024Review
- [Advances in hepatitis E epidemiology].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- Higher Risk of HEV Transmission and Exposure among Blood Donors in Europe and Asia in Comparison to North America: A Meta-Analysis.Pathogens (Basel, Switzerland) · 2023Review
- Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People's Democratic Republic: a hospital-based study.Archives of disease in childhood · 2023Article
- Transmission of Hepatitis E Virus.Advances in experimental medicine and biology · 2023Article
- Status of anti-HEV IgG and IgM antibodies among the hemodialysis patients in southwest region of Iran.Iranian journal of microbiology · 2022Article
- Transfusion-transmitted hepatitis E: What we know so far?World journal of gastroenterology · 2022Review
- Hepatitis E: Current Status in India.Clinical liver disease · 2021Review
- Setting a Course for Preventing Hepatitis E in Low and Lower-Middle-Income Countries: A Systematic Review of Burden and Risk Factors.Open forum infectious diseases · 2021Article
- Prevalence of Hepatitis E Virus Infection Among Blood Donors in the Eastern Province of Saudi Arabia.Journal of multidisciplinary healthcare · 2021Article
- Blood transfusion is unlikely to be a source for hepatitis E virus transmission in India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Article
- Hepatitis E virus: reasons for emergence in humans.Current opinion in virology · 2019Review
- Evaluating the economic viability of hepatitis E virus serological screening among blood donors: A prospective study from India for advancing blood safety.Asian journal of transfusion scienceArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis E virus (HEV) is transmitted primarily through contaminated water and food. Recently, HEV viremia in blood donors and transfusion-related transmission of HEV have been reported, leading to calls to screen donated blood for this virus. However, these data are from regions where genotype 3 HEV is predominant. In India, where human infections are caused only by genotype 1 HEV, the frequency of subclinical HEV viremia is unknown.
methodsMinipools of sera prepared from three donor units each from our institution's blood bank in Lucknow, India, were tested for HEV RNA using a sensitive amplification-based assay. A randomly selected subset was also tested for IgG anti-HEV antibodies using a commercial (Wantai) immunoassay.
resultsSera from 1799 donors (median [range] age 30 [18-63] years; 1746 [97.0%] men) were collected (June-July 2016, 900; November-December 2016, 899). Of these, 17 (0.95%), 16 (0.90%), and 3 (0.17%) tested positive for HBsAg, anti-HCV, and anti-HIV antibodies, respectively. None of the donors tested positive for HEV RNA. Of 633 randomly selected donors (age 30 [18-63] years, 613 [96.8%] male) tested for IgG anti-HEV, 383 (60.5%) tested positive. Seropositivity rate increased with age, being 70/136 (52%), 177/299 (59%), 100/154 (65%), 30/34 (88%), and 6/10 (60%) in the 18-24, 25-34, 35-44, 45-54, and 55 years or older age groups, respectively.
conclusionsIn healthy blood donors from northern India, HEV viremia is infrequent though anti-HEV antibody prevalence is high. This suggests that asymptomatic HEV viremia may be less frequent in areas with genotype 1 predominance than those with genotype 3 predominance.
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