Trial reportTechniques in coloproctology2018
Doppler-guided hemorrhoidal dearterialization with laser (HeLP): a prospective analysis of data from a multicenter trial.
Trial report in Techniques in coloproctology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03791775 (A Multicentre, Open-label, Single-arm Phase II Trial on the Efficacy and Safety of Sclerotherapy Using 3% Polidocanol Foam to Treat Second-degree Hemorrhoidal Disease), which is not on this map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicentre, Open-label, Single-arm Phase II Trial on the Efficacy and Safety of Sclerotherapy Using 3% Polidocanol Foam to Treat Second-degree Hemorrhoidal Disease
Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- The Italian Unitary Society of Colon-Proctology (Società Italiana Unitaria di Colonproctologia) guidelines for the management of acute and chronic hemorrhoidal disease.Annals of coloproctology · 2024Guideline
- Hemorrhoid laser dearterialization: systematic review and meta-analysis.Lasers in medical science · 2023Pooled it
- Non-excisional laser therapies for hemorrhoidal disease: a systematic review of the literature.Lasers in medical science · 2021Pooled it
- Clinical Outcomes and Effectiveness of Laser Treatment for Hemorrhoids: A Systematic Review.World journal of surgery · 2021Pooled it
- A multicentre, open-label, single-arm phase II trial of the efficacy and safety of sclerotherapy using 3% polidocanol foam to treat second-degree haemorrhoids (SCLEROFOAM).Techniques in coloproctology · 2022Trial
- Evaluating the effectiveness of oral phlebotonics for the conservative management of hemorrhoidal disease: insights from the VIVI2022/01/VIVALDI study.Frontiers in surgery · 2026Article
- The effect of endoscopic polidocanol carbon dioxide foam for internal hemorrhoids: a retrospective study.PeerJ · 2025Article
- Laser technology in proctological diseases: is it really the wave of the future?Updates in surgery · 2023Review
- Comprehensive literature review of the applications of surgical laser in benign anal conditions.Lasers in medical science · 2022Review
- Guidelines, guidelines and more guidelines for haemorrhoid treatment: A review to sort the wheat from the chaff.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Review
- Laser utility in the treatment of hemorrhoidal pathology: a review of literature.Lasers in medical science · 2022Review
- Hemorrhoid laser procedure (HeLP) for second- and third-degree hemorrhoids: results from a long-term follow-up analysis.Lasers in medical science · 2022Article
- Doppler-guided hemorrhoidal dearterialization with laser (HeLP): indications and clinical outcome in the long-term. Results of a multicenter trial.Surgical endoscopy · 2022Article
- The effects of laser procedure in symptomatic patients with haemorrhoids: A systematic review.Frontiers in surgery · 2022Review
- Preliminary Results of the First 50 Patients Undergoing Sclerotherapy for II-Degree Hemorrhoidal Disease Using an Automated Device.Frontiers in surgery · 2022Article
- Superior rectal artery embolization for bleeding internal hemorrhoids.Techniques in coloproctology · 2021Article
- Consensus statement of the Italian society of colorectal surgery (SICCR): management and treatment of hemorrhoidal disease.Techniques in coloproctology · 2020Review
- Hemorrhoid laser procedure with suture-pexy (HeLPexx): a novel effective procedure to treat hemorrhoidal disease.Techniques in coloproctology · 2020Article
- Offering HeLP to work out the optimum treatment for haemorrhoidal disease.Techniques in coloproctology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDoppler-guided hemorrhoidal laser procedure (HeLP) is a new minimally invasive technique to treat symptomatic hemorrhoids. The aim of this multicenter study was to prospectively assess clinical results and patients' satisfaction in patients treated with HeLP.
methodsIndications for HeLP included patients with symptomatic hemorrhoids resistant to medical therapy, with low-grade prolapse. Clinical efficacy was evaluated assessing resolution of symptoms and patient satisfaction. Frequency of bleeding and frequency of acute hemorrhoid-related symptoms were given a score of 0 to 4 (where 4 = more than 3 episodes/week) and 0 to 3 (where 3 = more than 5 episodes/year), respectively. Quality of life, pain at rest, and pain with evacuation were scored using a visual analogue scale (VAS) of 0 to 10. Intra- and postoperative complications were recorded. Potential predictive factors for failure were assessed.
resultsTwo hundred and eighty-four patients (183 males, 101 females) with a mean age of 47.5 years were included in the study. At 6-month follow-up, symptoms had completely resolved in 257/284 (90.5%) and 275/284 (96.8%) patients were satisfied with the results. An analysis of a subgroup of 144 patients followed up for a minimum of 12 months revealed a resolution of symptoms in 130/144 (90.3%) and satisfaction in 139/144 (96.5%). There was a statistically significant improvement of the bleeding score (from 2.4 ± 1.07 to 0.36 ± 0.49; p < 0.0001), acute symptoms score (from 2.03 ± 0.16 to 0.61 ± 0.59; p < 0.0001), quality of life (from 4.63 ± 1.32 to 8.96 ± 1.35; p < 0.0001), pain at rest (from 3.0 ± 2.05 to 1.1 ± 0.99; p < 0.0006), and pain with evacuation (from 4.8 ± 1.22 to 1.7 ± 1.15; p < 0.0001). No significant changes in continence and constipation were observed. Univariate analysis failed to show factors significantly associated with failure.
conclusionsThe HeLP procedure seems to be safe and effective in patients with symptomatic hemorrhoids. It is simple, minimally invasive, and relatively pain free. It can be performed in an ambulatory setting without anesthesia, and it achieves high patient satisfaction. It may, therefore, be considered a "first-line treatment" in all patients without significant hemorrhoidal prolapse in whom medical therapy has failed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.