Evidence map›Paper›PMID 30159434›Full record

ReviewNon-coding RNA research2018

Circular RNAs in the cardiovascular system.

Clarissa P C Gomes, Antonio Salgado-Somoza, Esther E Creemers, Christoph Dieterich, Mitja Lustrek, Yvan Devaux, Cardiolinc™ network

Erratum issuedAbstract readReview
In one paragraph

Review in Non-coding RNA research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Minor and major circRNAs in virus and host genomes.Journal of microbiology (Seoul, Korea) · 2021
    Review
  7. Article
  8. Review
  9. Article
  10. [CircRNA_005647 inhibits expressions of fibrosis-related genes in mouse cardiac fibroblastsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019
    Article
  11. Observational
  12. Noncoding RNAs in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2019
    Review
  13. Non-coding RNA involvement in the pathogenesis of diabetic cardiomyopathy.Journal of cellular and molecular medicine · 2019
    Review
  14. Review
  15. Review
  16. Review
  17. Role of circular RNAs in cardiovascular diseases.Experimental biology and medicine (Maywood, N.J.) · 2019
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Clarissa P C GomesCardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg.
Antonio Salgado-SomozaCardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg.
Esther E CreemersExperimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
Christoph DieterichGerman Center for Cardiovascular Research, University Hospital Heidelberg, Heidelberg, Germany.
Mitja LustrekDepartment of Intelligent Systems, Jozef Stefan Institute, Ljubljana, Slovenia.
Yvan DevauxCardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg.
Cardiolinc™ network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Until recently considered as rare, circular RNAs (circRNAs) are emerging as important regulators of gene expression. They are ubiquitously expressed and represent a novel branch of the family of non-coding RNAs. Recent investigations showed that circRNAs are regulated in the cardiovascular system and participate in its physiological and pathological development. In this review article, we will provide an overview of the role of circRNAs in cardiovascular health and disease. After a description of the biogenesis of circRNAs, we will summarize what is known of the expression, regulation and function of circRNAs in the cardiovascular system. We will then address some technical aspects of circRNAs research, discussing how artificial intelligence may aid in circRNAs research. Finally, the potential of circRNAs as biomarkers of cardiovascular disease will be addressed and directions for future research will be proposed.

Indexed as

Artificial intelligenceBiomarkerCardiovascular diseaseCardiovascular systemcircRNAs, circular RNAsCircular RNAsCRISPR, clustered regularly interspaced short palindromic repeatsCV, cardiovascularDCM, dilated cardiomyopathyEMT, epithelial-mesenchymal transitionlncRNAs, long non-coding RNAsmiRNAs, microRNAsncRNAs, non-coding RNAsNon-coding RNAsRNA-seq, RNA sequencingRPAD, RNase R treatment followed by polyadenylation and poly(A)+ RNA depletionRT-qPCR, reverse transcription quantitative polymerase chain reaction

Identifiers

PMID30159434
PMCPMC6084836

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.