Evidence map›Paper›PMID 30159410›Full record

ReviewNon-coding RNA research2016

Long non-coding RNAs: Mechanism of action and functional utility.

Shakil Ahmad Bhat, Syed Mudasir Ahmad, Peerzada Tajamul Mumtaz, Abrar Ahad Malik, Mashooq Ahmad Dar, Uneeb Urwat, Riaz Ahmad Shah, Nazir Ahmad Ganai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Non-coding RNA research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 1 synthesis or guideline pooled it.

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112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shakil Ahmad BhatDivision of Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry, Shuhama, Sher-e- Kashmir University of Agricultural Sciences and Technology, Kashmir, 19006, India.
Syed Mudasir AhmadDivision of Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry, Shuhama, Sher-e- Kashmir University of Agricultural Sciences and Technology, Kashmir, 19006, India.
Peerzada Tajamul MumtazDivision of Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry, Shuhama, Sher-e- Kashmir University of Agricultural Sciences and Technology, Kashmir, 19006, India.
Abrar Ahad MalikDivision of Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry, Shuhama, Sher-e- Kashmir University of Agricultural Sciences and Technology, Kashmir, 19006, India.
Mashooq Ahmad DarDivision of Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry, Shuhama, Sher-e- Kashmir University of Agricultural Sciences and Technology, Kashmir, 19006, India.
Uneeb UrwatDivision of Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry, Shuhama, Sher-e- Kashmir University of Agricultural Sciences and Technology, Kashmir, 19006, India.
Riaz Ahmad ShahDivision of Biotechnology, Faculty of Veterinary Sciences and Animal Husbandry, Shuhama, Sher-e- Kashmir University of Agricultural Sciences and Technology, Kashmir, 19006, India.
Nazir Ahmad GanaiDivision of Animal Breeding and Genetics, Faculty of Veterinary Sciences and Animal Husbandry, Shuhama, Sher-e- Kashmir University of Agricultural Sciences and Technology, Kashmir, 190006, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent RNA sequencing studies have revealed that most of the human genome is transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long non-coding RNAs (lncRNAs) are non-coding transcripts longer than 200 nucleotides. Members of the non-coding genome include microRNA (miRNA), small regulatory RNAs and other short RNAs. Most of long non-coding RNA (lncRNAs) are poorly annotated. Recent recognition about lncRNAs highlights their effects in many biological and pathological processes. LncRNAs are dysfunctional in a variety of human diseases varying from cancerous to non-cancerous diseases. Characterization of these lncRNA genes and their modes of action may allow their use for diagnosis, monitoring of progression and targeted therapies in various diseases. In this review, we summarize the functional perspectives as well as the mechanism of action of lncRNAs.

Indexed as

CancerGenome imprintingImmunityLncRNATranscription regulationX-chromosome inactivation

Identifiers

PMID30159410
PMCPMC6096411

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.