Evidence map›Paper›PMID 30159408›Full record

ReviewNon-coding RNA research2016

Current state of phenolic and terpenoidal dietary factors and natural products as non-coding RNA/microRNA modulators for improved cancer therapy and prevention.

Bernhard Biersack

Open access · goldAbstract readReview
In one paragraph

Review in Non-coding RNA research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Zygo-Albuside A: New Saponin fromInternational journal of molecular sciences · 2022
    Article
  7. Plants (Basel, Switzerland) · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Targeting miRNA by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver.Evidence-based complementary and alternative medicine : eCAM · 2021
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Integrative cancer therapies
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Bernhard BiersackOrganic Chemistry Laboratory, University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany.
University of Bayreuth · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The epigenetic regulation of cancer cells by small non-coding RNA molecules, the microRNAs (miRNAs), has raised particular interest in the field of oncology. These miRNAs play crucial roles concerning pathogenic properties of cancer cells and the sensitivity of cancer cells towards anticancer drugs. Certain miRNAs are responsible for an enhanced activity of drugs, while others lead to the formation of tumor resistance. In addition, miRNAs regulate survival and proliferation of cancer cells, in particular of cancer stem-like cells (CSCs), that are especially drug-resistant and, thus, cause tumor relapse in many cases. Various small molecule compounds were discovered that target miRNAs that are known to modulate tumor aggressiveness and drug resistance. This review comprises the effects of naturally occurring small molecules (phenolic compounds and terpenoids) on miRNAs involved in cancer diseases.

Indexed as

1,25-D, 1,25-dihydroxyvitamin D318-AGA, 18α-glycyrrhetinic acid3,6-DHF, 3,6-dihydroxyflavoneAKBA, 3-acetyl-11-keto-β-boswellic acidAnticancer drugsCAPE, caffeic acid phenethyl esterCDODA-Me, methyl 2-cyano-3,11-dioxo-18β-olean-1,12-dien-30-oateDox, doxorubicinEGCG, (−)-epigallocatechin-3-O-gallateMicroRNAPEG, polyethylene glycolPolyphenolsPPAP, polycyclic polyprenylated acylphloroglucinolRA, retinoic acidROS, reactive oxygen speciesTerpenesTQ, thymoquinone

Identifiers

PMID30159408
PMCPMC6096431
OpenAlexW2504402913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.