Evidence map›Paper›PMID 30159384›Full record

ArticleACS biomaterials science & engineering2018

Cell Membrane-Based Nanoreactor To Mimic the Bio-Compartmentalization Strategy of a Cell.

Vimalkumar Balasubramanian, Andrea Poillucci, Alexandra Correia, Hongbo Zhang, Christian Celia, Hélder A Santos

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vimalkumar BalasubramanianDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, and Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Viikinkaari 5E, Helsinki FI-00014, Finland.
Andrea PoillucciDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, and Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Viikinkaari 5E, Helsinki FI-00014, Finland.
Alexandra CorreiaDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, and Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Viikinkaari 5E, Helsinki FI-00014, Finland.
Hongbo ZhangDepartment of Pharmaceutical Science, Åbo Akademy University, BioCity, Artillerigatan 6A, Turku FI-20520, Finland.
Christian CeliaDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Via dei Vestini 31, Chieti I-66100, Italy.
Hélder A SantosDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, and Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Viikinkaari 5E, Helsinki FI-00014, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organelles of eukaryotic cells are structures made up of membranes, which carry out a majority of functions necessary for the surviving of the cell itself. Organelles also differentiate the prokaryotic and eukaryotic cells, and are arranged to form different compartments guaranteeing the activities for which eukaryotic cells are programmed. Cell membranes, containing organelles, are isolated from cancer cells and erythrocytes and used to form biocompatible and long-circulating ghost nanoparticles delivering payloads or catalyzing enzymatic reactions as nanoreactors. In this attempt, red blood cell membranes were isolated from erythrocytes, and engineered to form nanoerythrosomes (NERs) of 150 nm. The horseradish peroxidase, used as an enzyme model, was loaded inside the aqueous compartment of NERs, and its catalytic reaction with Resorufin was monitored. The resulting nanoreactor protected the enzyme from proteolytic degradation, and potentiated the enzymatic reaction in situ as demonstrated by maximal velocity (

Identifiers

PMID30159384
PMCPMC6108536

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.