ArticleInternational journal of particle therapy2018
Investigating Dependencies of Relative Biological Effectiveness for Proton Therapy in Cancer Cells.
Article in International journal of particle therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Commissioning of a Monte Carlo-based scanning proton beam for breast cancer: Incorporating LETd calculations and variable RBE models.Journal of applied clinical medical physics · 2026Article
- Radiobiological characterisation of a 28 MeV proton beam delivered by the MC-40 cyclotron.Cell death discovery · 2025Article
- Significance of the proton energy loss mechanism to gold nanoparticles in proton therapy: a Geant4 simulation.Scientific reports · 2024Article
- Comparison of the Medical Uses and Cellular Effects of High and Low Linear Energy Transfer Radiation.Toxics · 2022Review
- Reformulated McNamara RBE-weighted beam orientation optimization for intensity modulated proton therapy.Medical physics · 2022Article
- Mechanisms and Review of Clinical Evidence of Variations in Relative Biological Effectiveness in Proton Therapy.International journal of radiation oncology, biology, physics · 2022Review
- Proton induced DNA double strand breaks at the Bragg peak: Evidence of enhanced LET effect.Frontiers in oncology · 2022Article
- Article
- Update of the particle irradiation data ensemble (PIDE) for cell survival.Journal of radiation research · 2021Article
- Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining.Cancer research · 2021Article
- Silicon 3D Microdetectors for Microdosimetry in Hadron Therapy.Micromachines · 2020Review
- Proton RBE dependence on dose in the setting of hypofractionation.The British journal of radiology · 2020Review
- A High-Precision Method for In Vitro Proton Irradiation.International journal of particle therapy · 2020Article
- Phantom design and dosimetric characterization for multiple simultaneous cell irradiations with active pencil beam scanning.Radiation and environmental biophysics · 2019Article
- Physical and biological impacts of collimator-scattered protons in spot-scanning proton therapy.Journal of applied clinical medical physics · 2019Article
- Incorporation of Biologic Response Variance Modeling Into the Clinic: Limiting Risk of Brachial Plexopathy and Other Late Effects of Breast Cancer Proton Beam Therapy.Practical radiation oncologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeRelative biological effectiveness (RBE) accounts for the differences in biological effect from different radiation types. The RBE for proton therapy remains uncertain, as it has been shown to vary from the clinically used value of 1.1. In this work we investigated the RBE of protons and correlated the biological differences with the underlying physical quantities. MATERIALS AND
methodsThree cell lines were irradiated (CHO, Chinese hamster ovary; A549, human lung adenocarcinoma; and T98, human glioma) and assessed for cell survival by using clonogenic assay. Cells were irradiated with 71- and 160-MeV protons at depths along the Bragg curve and 6-MV photons to various doses. The dose-averaged lineal energy (
resultsProton RBE values ranged from 0.89 to 2.40. The RBE for all 3 cell lines increased with decreasing proton energy and was higher at 50% survival than at 10% survival. Additionally, both A549 and T98 cells generally had higher RBE values relative to the CHO cells, indicating a greater biological response to protons. An increase in RBE corresponded with an increase in
conclusionProton RBE was found to depend on mean proton energy, survival end point, and cell type. Changes in both
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