Evidence map›Paper›PMID 30159104›Full record

ArticleJournal of berry research2018

An immunological perspective for preventing cancer with berries.

Pan Pan, Yi-Wen Huang, Kiyoko Oshima, Martha Yearsley, Jianying Zhang, Jianhua Yu, Mark Arnold, Li-Shu Wang

Abstract read
In one paragraph

Article in Journal of berry research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Cancer prevention: past challenges and future directions.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Pan PanDepartment of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Yi-Wen HuangDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA.
Kiyoko OshimaDepartment of Pathology, John Hopkins University, Baltimore, MD, USA.
Martha YearsleyDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Jianying ZhangCenter for Biostatistics, The Ohio State University, Columbus, OH, USA.
Jianhua YuDepartment of Internal Medicine, Division of Hematology, College of Medicine, Comprehensive Cancer Center and The James Cancer Hospital, The Ohio State University, Columbus, OH, USA.
Mark ArnoldDepartment of Surgery, The Ohio State University, OH, USA.
Li-Shu WangDepartment of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
The Ohio State University · USMedical College of Wisconsin · USJohns Hopkins University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Mechanisms of tumor suppressor gene reactivation in colon cancer by berriesR01CA148818 · NCI · OHIO STATE UNIVERSITY · PI WANG, LI-SHU · 2010 to 2014
$1.5M
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA148818
6 · The paper itself

Abstract

Berries and their phytochemicals have well documented chemopreventive roles, but understanding their ability to regulate cancer immunology is only beginning to be explored. The literature, including human studies, suggests that berry components can modulate our immune system to delay cancer development. Moreover, their wide spectrum of phytochemicals suggests that they might influence the functions of multiple immune cells and different aspects of cancer immunity. Cancer immune-therapies are showing promise for some types of cancer because they boost T cells' ability to recognize tumor cells - an essential prelude to destruction. Recognition occurs after dendritic cells present antigen, such as tumor antigen, to T cells, generating an adaptive response. Therefore, the potential of berries to aid cancer immune-therapies by, for example, regulating dendritic cells, warrants further investigation in animal and human studies. More information is also needed about berries' effects on the entire spectrum of immunity so that a comprehensive view can inform efforts to use berries to enhance immune responses during cancer prevention and treatment. This review summarizes the effects of berries as anti-tumor agents from the immunological perspective in tumor-bearing animals and humans.

Identifiers

PMID30159104
PMCPMC6110394
OpenAlexW2809870915

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.