Evidence map›Paper›PMID 30159092›Full record

ArticleThe open cardiovascular medicine journal2018

Biomarkers and Gene Polymorphisms in Members of Long- and Short-lived Families: A Longevity Study.

Vana Kolovou, Olga Diakoumakou, Athanasia K Papazafiropoulou, Niki Katsiki, Elisabeth Fragopoulou, Ioannis Vasiliadis, Dimitris Degiannis, Leonidas Duntas, Smaragdi Antonopoulou, Genovefa Kolovou

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PubMed Full text at PMC Publisher
In one paragraph

Article in The open cardiovascular medicine journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. New Therapeutic Approaches and Biomarkers for Increased Healthspan.Advances in experimental medicine and biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Vana KolovouMolecular Immunology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece.
Olga DiakoumakouCardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
Athanasia K Papazafiropoulou1 Department of Internal Medicine and Diabetes Center, Tzaneio General Hospital of Piraeus, Piraeus, Greece.
Niki Katsiki2 Propedeutic Department of Internal Medicine, Hippokration University Hospital, Thessaloniki, Greece.
Elisabeth FragopoulouDepartment of Science Nutrition-Dietetics, Harokopio University, Athens, Greece.
Ioannis VasiliadisCardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
Dimitris DegiannisMolecular Immunology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece.
Leonidas DuntasEvgenideion Hospital, Unit of Endocrinology Diabetes and Metabolism, University of Athens, Athens, Greece.
Smaragdi AntonopoulouDepartment of Science Nutrition-Dietetics, Harokopio University, Athens, Greece.
Genovefa KolovouCardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
Onassis Cardiac Surgery Center · GRHarokopio University of Athens · GRHippocration General Hospital · GRNational and Kapodistrian University of Athens · GRTzaneion General Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe influence of biomarkers in human lifespan has been investigated but with no clear results yet. MATERIALS AND

methodsLipids, Uric Acid (UA), Adiponectin (ADIPOQ), Insulin-like Growth Factor (IGF-1), cholesteryl ester transfer protein (CETP) and angiotensin-converting enzyme (ACE) proteins, as well as

resultsSerum CETP and IGF-1 levels were lower, whereas AdipoQ concentrations were higher in P compared with FL1 and FL2 members (CETP: p = 0.03 for both comparisons; IGF-1 p < 0.001 for both comparisons and ADIPOQ: p = 0.001 and p = 0.004, respectively). Furthermore, serum triglycerides, UA and glucose concentrations were higher in FD1 compared with FD2 subjects (p=0.001, 0.02 and ≤0.001, respectively). In FD2 and FL2, CETP levels were lower in individuals with

conclusionIncrease serum TGs, UA and GL concentrations were higher in the middle-aged individuals compared with their children in families independently of their lifespan. The serum adiponectin concentration was the highest in the oldest old individuals implying beneficial influence on lifespan. Independently of family's lifespan history, the youngest individuals with

Indexed as

AdiponectinAngiotensin-converting enzymeCholesteryl ester transfer proteinInsulin-like growth factorInsulin-like growth factor binding protein-3 genesLifespanLongevityUric acid

Identifiers

PMID30159092
PMCPMC6080062
OpenAlexW2887335899

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.