Evidence map›Paper›PMID 30158994›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2018

Combined Donepezil and Ethanolic Extract of Propolis Improved Memory Better Than Donepezil and Propolis Monotherapy in Wild Type

Emmanuel Tiyo Ayikobua, Ibrahim Semuyaba, Daniel Ejike Eze, Muhamudu Kalange, Mariam Nansunga, Alfred Omachonu Okpanachi, Abass Alao Safiriyu

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Emmanuel Tiyo AyikobuaDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, P.O. Box 71, Bushenyi, Uganda.ORCID 0000-0002-4743-9622
Ibrahim SemuyabaDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, P.O. Box 71, Bushenyi, Uganda.ORCID 0000-0002-6606-8265
Daniel Ejike EzeDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, P.O. Box 71, Bushenyi, Uganda.
Muhamudu KalangeDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, P.O. Box 71, Bushenyi, Uganda.ORCID 0000-0002-8647-0956
Mariam NansungaDepartment of Physiology, Faculty of Biomedical Sciences, St. Augustine International University, P.O. Box 88, Kampala, Uganda.
Alfred Omachonu OkpanachiDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, P.O. Box 71, Bushenyi, Uganda.
Abass Alao SafiriyuDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, P.O. Box 71, Bushenyi, Uganda.ORCID 0000-0002-6042-074X
Kampala International University · UGSt. Augustine International University · UG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDonepezil is the most common drug used in the treatment of disorders associated with memory loss, especially that in Alzheimer's disease. Healthy individuals however have continued to use it as a memory enhancer. This study was aimed at evaluating the combined therapy of donepezil and propolis on cognition in

resultsThe results obtained showed that the combination of propolis with donepezil caused a remarkable improvement in both the short- and long-term memory. In addition, there was a dose dependent improvement with the administration of propolis.

conclusionPropolis extract obtained from different parts of Uganda expressed cognitive improvement when coadministered with donepezil in wild type

Identifiers

PMID30158994
PMCPMC6109536
OpenAlexW2886658595

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.